HCS in Super Resolution : An ultra-high resolution screening platform prototype to quantify the mobility of active proteins within living cells
This project consists of a unique Super Resolution Screening platform based on sptPALM technology that allows single protein mobility quantification within living cells in multiwell plates. Developed in close collaboration between optical and neurosciences research teams and industrial partners, this project combines instrumental and analytical tools to screen molecules for therapeutics of pathologies such as neurodegenerative diseases, diabetes, oncology, cardiology and immunology. The final goal of the project is to deliver a patented fully-automated platform prototype and to provide a new screening method to the pharmaceutical industry.
Anne Beghin is a multidisciplinary PhD scientist with ten years of extensive research experience in industry, microscopy platforms and academia. She obtained her PhD in cancerology in 2007, at the University Claude Bernard in Lyon. She then moved to optical microscopy by integrating, as team leader, the microcopy platform of Université de Lyon, where she developed image analysis services and live microscopy during 4 years. She established numerous collaborations with academic labs and industrial partners to develop interdisciplinary research programs at the interface between cellular biology, optical microscopy, image processing and data analysis. In 2011, she was recruited by a biotechnology company based in Bordeaux during 2 years where she was in charge of a tissue analysis service: from biologic samples (whole tissue sections and Tissue Micro Arrays) to image acquisition and analysis with database establishment. She has been part of the IINS (at the interface between JB Sibarita and D Choquet teams) since March 2014. She is the project leader of the HCS_Super Resolution project. She is author of ten publications in microscopy, neuroscience and cancerology review. More details on her LinkedIn.