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Ventral subiculum stimulation - Cell Report, November 2015

Ventral subiculum stimulation - Cell Report, November 2015


Ventral subiculum stimulation promotes persistent hyperactivity of dopamine neurons and facilitates behavioral effects of cocaine


The ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circuits and synaptic mechanisms by which vSUB alters the excitability of dopamine neurons is a necessary step to understand the motor changes induced by cocaine. Here, we report that high-frequency stimulation of the vSUB (HFSvSUB) over-activates ventral tegmental area (VTA) dopamine neurons in vivo and triggers long-lasting modifications of synaptic transmission measured ex vivo. This potentiation is caused by NMDA-dependent plastic changes occurring in the bed nucleus of the stria terminalis (BNST). Finally, we report that the modification of the BNST-VTA neural circuits induced by HFSvSUB potentiates locomotor activity induced by a sub-threshold dose of cocaine. Our findings unravel a neuronal circuit encoding behavioral effects of cocaine in rats and highlight the importance of adaptive modifications in the BNST, a structure that influences motivated behavior as well as maladaptive behaviors associated with addiction.

Leg. Brain network underlying the hyperactivity of dopamine producing neurons and the behavioral effect of cocaine


Authors:
Glangetas C, Fois GR, Jalabert M, Lecca S, Valentinova K, Meye FJ, Diana M, Faure P, Mameli M, Caille S, Georges F.


Contact:
Francois Georges

- More informations here:
Cell Reports (2015) DOI: http://dx.doi.org/10.1016/j.celrep.2015.10.076 & Pubmed
CNRS press release in French here