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Home > TEAMS > TEAM CHOQUET > RESEARCH AXES > Cytoskeleton and membrane interplay in synaptic organization and transmission

Cytoskeleton and membrane interplay in synaptic organization and transmission






Contact: Anna BRACHET

Tel. (+33)5 05 33 51 XX XX







Scientific Context



The Cytoskeleton axis is integrated into the Dynamics of Synapse Organization and Function group .

This activity is headed by Anna Brachet (CR2, senior researcher). Her objective is to study the role of cytoskeleton proteins and their interactions with the membrane in the dynamic regulation of dendritic spine morphology and physiology.



This activity is currently funded by the BRAIN Labex.



Selected Publications

LTP induction triggers cholesterol redistribution activating Cdc42 and driving AMPA receptor synaptic delivery.
Brachet A, Norwood S, Brouwers JF, Palomar E, Helms JB, Dotti CG and Esteban JA. The Journal of Cell Biology 2015, Mars16;208(6):791-806. (F1000)


Tetrodotoxin-resistant voltage gated sodium channel Nav1.8 constitutively interacts with ankyrin G.
Montersino A, Brachet A, Fache MP, Angles d’Ortoli S, Liu W, Feracci G, Rueda-Boroni F, Castets F and Dargent B. The Journal of Neurochemistry 2014 June 5; 131:33-41.

Determinants of voltage-gated sodium channel clustering in neurons.
Leterrier C, Brachet A, Dargent B and Vacher H. Seminars in Cell and Developmental Biology 2011 Apr;22(2):171-7.