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How to square super-resolution microscopy? - Nature Methods, October 2019

How to square super-resolution microscopy? - Nature Methods, October 2019

A super-resolution platform for correlative live single-molecule imaging and STED microscopy

Super-resolution microscopy offers tremendous opportunities to unravel the complex and dynamic architecture of living cells. However, current super-resolution microscopes are well suited for revealing protein distributions or cell morphology, but not both. We present a super-resolution platform that permits correlative single-molecule imaging and stimulated emission depletion microscopy in live cells. It gives nanoscale access to the positions and movements of synaptic proteins within the morphological context of growth cones and dendritic spines.

Fig: Multi-modal super-resolution imaging to reveal nanoscale morphology
and molecular organisation of synapses


V. V. G. Krishna Inavalli , Martin O. Lenz , Corey Butler , Julie Angibaud, Benjamin Compans , Florian Levet , Jan Tønnesen , Olivier Rossier , Gregory Giannone, Olivier Thoumine, Eric Hosy , Daniel Choquet , Jean-Baptiste Sibarita  and U. Valentin Nägerl   

- Direct link to the article here
- Contacts: Jean-Baptiste Sibarita & Valentin Nägerl, IINS