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Huntington’s disease - Nature Communications 2018

Huntington's disease - Nature Communications 2018

Huntington’s disease: correct the abnormal mobility of glutamate receptors to improve early cognitive deficits?

Huntington’s disease is a hereditary neurodegenerative disease that causes cognitive and psychiatric disorders, and uncontrolled movements. Combining high resolution microscopy with pharmacological approaches, a national and international collaboration has discovered the mechanism responsible for the dysfunction of synapses in neuronal models of Huntington’s disease. Researchers have identified a molecule capable to improve cognitive functions in Huntington’s disease mouse models. These results are published in the journal Nature Communications (online).

Fig: movement of glutamate receptors (in purple) recorded on the surface of hippocampal neurons expressing the huntingtin protein mutated in Huntington’s disease. Left, the high movement of receptors reflects the pathological state of the neurons. Rigth, in the presence of Tianeptine, normal movement of receptors is restored.
© Hongyu Zhang & Daniel Choquet (Creative Commons)

- Contact: Daniel Choquet
- Nature Communications: Modulation of AMPA receptor surface diffusion restored hippocampal plasticity and memory in Huntington’s disease model
Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthew Sainlos, Dolors Grillo-Bosch, Sophie Inc, Françoise Coussen, Denis J. David, Cho Yoon, Frederic Saudou, Yann Humeau, Daniel Choquet

+ More details in English and on the CNRS website in French