Glutamate receptor conformation regulates their mobility to fine tune synaptic transmission.
AMPA receptors are tetrameric ion channels gated by glutamate that mediate the majority of excitatory neurotransmission. Their mobility was discovered in Bordeaux more than a decade ago and postulated to tune frequency dependent synaptic transmission. However, how could AMPA receptors exchange within tens of milliseconds in front of glutamate release sites has remained mysterious and intrigued physiologists in the last years. This study now provides a molecular mechanism to explain the interplay between AMPA receptor dynamic organization, activation and synaptic transmission. In a multidisciplinary approach associating many of the members of the team “Dynamic Organization of Synapses” at the Interdisciplinary Institute for Neuroscience, Daniel Choquet and Eric Hosy have co-supervised a study combining superresolution imaging, cell biology, biochemistry and electrophysiology to unravel the impact of AMPA receptor conformation on their surface trafficking
Audrey Constals, Andrew C. Penn, Benjamin Compans, Estelle Toulmé, Amandine Phillipat, Sébastien Marais, Natacha Retailleau, Anne-Sophie Hafner, Françoise Coussen, Eric Hosy, Daniel Choquet
Eric Hosy ,Daniel Choquet
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