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News before 2017

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Nature - June 2014

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

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Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity - March 2016

How are stabilized AMPA receptors at synapses? Glutamate receptors of AMPA type (AMPAR) are the main players of synaptic transmission in mammalian brain. Their numbers at the synapse largely (...)

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PGE2-EP3 pathway impairs hippocampal synaptic plasticity in AD's mouse - Neurobiology of Aging, 2016

PGE2-EP3 pathway impairs hippocampal synaptic plasticity in AD’s mouse - Neurobiology of Aging, 2016

PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease (...)

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Carbon nanotubes reveal intimate domains of the brain - Nature Nanotechnology, Nov. 2016

Carbon nanotubes reveal intimate domains of the brain - Nature Nanotechnology, Nov. 2016

Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain
The brain is a dynamic structure with the extracellular space (ECS) taking up almost a (...)

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Scientific Reports - September 2016

Induction of hippocampal long-term potentiation increases the morphological dynamics of microglial processes and prolongs their contacts with dendritic spines
Recently microglia, the resident (...)

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Research from IINS in the public eye

Research from IINS in the public eye

SCIENCE & VIE, the leading popular science magazine in France, just ran a story on super-resolution microscopy, highlighting the work of the Nagerl team on STED microscopy.
See more info at: (...)

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PRIMO, a new device for creating photopatterns for cellular assays

PRIMO, a new device for creating photopatterns for cellular assays

Alvéole launches PRIMO, a new device for creating photopatterns for cellular assays.
Founded in 2010 by three researchers from CNRS, Dr. Maxime Dahan, a cell imaging specialist, Dr. Vincent (...)

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International Bio-Imaging Master Program

This master is housed by the University of Bordeaux, in a gorgeous vineyard areain the South-West of France, 40 miles from the sea-side and 130 miles from the Pyrenean Mountains and Spain, in a (...)

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FRM Teams 2016: 3 teams selected at IINS

FRM Teams 2016: 3 teams selected at IINS

Among the 4 Bordeaux Neurocampus teams selected by the FRM in 2016, 3 are from IINS:
Christophe Mulle team project: Synaptic circuits of memory in physiological conditions and in Alzheimer’s (...)

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Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices - March 2016

Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices - March 2016

Single molecule imaging techniques (2014 Nobel Laureates in Chemistry) have changed the way we understand many biological mechanisms, particularly in neurobiology, by shedding light on intricate (...)

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The Marcel Dassault 2015 prize to Laurent Groc

The Marcel Dassault 2015 prize to Laurent Groc

Laurent Groc, head of the team "Development and Adaptation of Neuronal Connections", has been awarded of the 2015 Marcel Dassault Prize, which is the highest French award for innovative research (...)

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Ventral subiculum stimulation - Cell Report, November 2015

Ventral subiculum stimulation - Cell Report, November 2015

Ventral subiculum stimulation promotes persistent hyperactivity of dopamine neurons and facilitates behavioral effects of cocaine
The ventral subiculum (vSUB) plays a key role in addiction, and (...)

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Nature-Methods, September 2015 - SR-Tesseler

SR-Tesseler: a method to segment and quantify localization-based super-resolution microscopy data
Due to the diffraction of light, the resolution of conventional light microscopy is limited as (...)

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Methods, June 2015 - STED microscopy for nanoscale imaging in living brain slices

Stimulated emission depletion (STED) microscopy was the first fluorescence microscopy technique to break the classic diffraction barrier of light microscopy. Even though STED was conceived more (...)

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Nature Methods - May 2015 - High- and super-resolution imaging using single-objective SPIM

Selective-Plane Illumination Microscopy (SPIM) is a recent but well established 3D imaging technique, awarded method of the year 2015. Due to its high sensitivity and very efficient background (...)

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Neuron - April 2015 - Stargazin interaction with PSD-95 unveiled

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95
Neuron online April 02, 2015 http://www.cell.com/neuron/abstract...

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Neuron - Feb. 2015 AMPA receptor conformation and mobility

Glutamate-Induced AMPA Receptor Desensitization Increases Their Mobility and Modulates Short-Term Plasticity through Unbinding from Stargazin
Neuron 85, 1–17, February 18, 2015 > (...)

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The Journal of Cell Biology – November 2014

pHuji, a pH-sensitive red fluorescent protein for imaging of exo- and endocytosis
The Journal of Cell Biology – November 2014. doi:10.1083/jcb.201404107
Fluorescent proteins with pH-sensitive (...)

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EMBO Journal - October 2014

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion
EMBO Journal - October 2014. doi 10.15252/embj.201488837
Actin dynamics drive (...)

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Nature - August 2014

Sensory-evoked LTP driven by dendritic plateau potentials in vivo
Nature 2014 Aug 31. doi: 10.1038/nature13664
Long-term synaptic potentiation (LTP) is thought to be a key process in cortical (...)

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