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Presentation of the institute



Olfaction and Memory

TEAM Lisa Roux

Project Summary

The ability to store and retrieve associations between specific sensory stimuli and behaviorally relevant information is a vital memory function: it allows the organism to adapt its behavior based on prior experience. Olfaction is a central sensory modality in rodents as it supports an array of crucial behaviors such as predator avoidance, feeding, reproduction, maternal behavior and social interactions. Although specific odors can trigger innate responses, most odor stimuli acquire behavioral significance upon learning and experience. The goal of our team is to identify the network mechanisms underlying the formation of olfactory memory traces across distributed brain regions. More generally, we aim at understanding how sensory information is routed and processed in the brain to integrate lasting memories.
To adress these questions, we use a combination of advanced methods that allow monitoring and manipulating in real-time neuronal ensembles in freely moving animals towards a deep mechanistic understanding of brain functions. These methods include chronic multi-site high-density silicon probe recordings (units and local field potentials), 3D behavioral tracking, optogenetic tagging and closed-loop optogenetic manipulations in behaving rodents.

Our work is funded by the Conseil Régional de la Nouvelle Aquitaine (Neurocampus project), the Initiative of Excellence of Bordeaux University (2017 Bordeaux Junior Chairs Program) and the ATIP-Avenir Program.

Team leader: Lisa Roux


During her PhD (Giaume Lab, Collège de France, France), Lisa Roux worked on neuro-glial interactions in the olfactory system using primarily slice electrophysiology methods (patch clamp, field recordings). Specifically, her PhD work on the olfactory bulb showed that astrocyte networks have specific rules of anatomical organization and are dynamically regulated, alongside with their neuronal partners (Roux et al., 2011, PNAS). She also unraveled a bi-directional loop of interactions between neurons and astrocytes, where astrocyte connexin hemichannels were both targets and modulators of neuronal circuit function (Roux et al., J. Neurosci., 2015). These novel mechanisms of neuroglial interactions could influence olfactory information processing by directly impacting the output of the olfactory bulb.
As a postdoc in the Buzsáki Lab (New York University, U.S.A.), Lisa Roux used cutting-edge in vivo electrophysiology and optogenetic approaches in the freely moving mouse to understand the mechanisms of hippocampal oscillations and their function in spatial memory processes. Her initial work as a postdoctoral fellow in Buzsáki Lab made important contributions to the understanding of the cellular mechanisms involved in two types of network oscillations, fundamental to memory function in the hippocampus: theta and sharp wave ripple oscillations (Stark et al., 2013, Neuron; Stark*, Roux*, Eichler* et al., 2014, Neuron, *equal contribution; Stark, Roux et al., 2015, PNAS). The role played by inhibitory interneurons in shaping circuit functions in the behaving animal was at the core of this work (Roux et al., 2014, Curr Opin Neurobiol ; Roux et al., 2015, Neuropharmacology). More recently, Lisa Roux uncovered a key role played by sharp wave ripple oscillations in the maintenance of the hippocampal “cognitive map” during spatial learning (Roux et al., 2017, Nature Neuroscience). As an independent group leader at the IINS, she broadened her field of investigation by studying the neuronal substrates of olfactory memory formation.
Lisa Roux has been the recipient of several prestigious fundings and awards, including Bettencourt-Schueller Foundation Award for Young Scientists (2013, France), the K99 National Institute of Health Pathway to Independence Award (2015, U.S.A.), a Junior Chair by the Initiative of Excellence of the Bordeaux University (2017, France) and the ATIP-Avenir Grant (2017, France). She has been selected to launch a research team at the IINS within the Bordeaux Neurocampus and was recruited at CNRS in 2017.

- See the Fondation Bettencourt Schueller News (May 15, 2018) here: "Portrait inspirant d’une chercheuse lauréate du Prix pour les jeunes chercheurs"

Tel: +33 (0) (office) or +33 (0)6 (mobile) – to be updated
Address: Institut Interdisciplinaire de NeuroSciences (IINS)
UMR 5297 CNRS/Université de Bordeaux
Centre Broca Nouvelle-Aquitaine
146 rue Léo Saignat - CS 61292 CASE 130
33077 Bordeaux, France

The team...

- See the Bordeaux Neurocampus presentation in French: Une nouvelle équipe à l’IINS : Olfaction et mémoire

Keys Publications

Roux L., Hu B., Eichler R., Stark E., Buzsáki G. Sharp wave ripples during learning stabilize the hippocampal spatial map. Nature Neuroscience, 20(6):845-853 (2017)

Stark E., Roux L., Eichler R., Buzsáki G. Local generation of multi-neuronal spike sequences in the hippocampal CA1 region. Proc Natl Acad Sci U S A. , 112(33):10521-6 (2015)

Roux L., Madar A., Lacroix MM, Chenju Y., Benchenane K., Giaume C. Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations. J Neurosci. , 35(46):15339-52 (2015)

Stark E.*, Roux L.*, Eichler R.*, Senzai Y., Royer S., Buzsáki G. (*equal contribution) Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations. Neuron, 83(2):467-80 (2014)

Roux L., Stark E., Sjulson L., Buzsáki G. In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes. Curr Opin Neurobiol. , 26C:88-95 (2014)

Stark E., Eichler R., Roux L., Fujisawa S., Rotstein HG, Buzsáki G. Inhibition-induced theta resonance in cortical circuits. Neuron, 80(5):1263-76 (2013)

Roux L., Benchenane K., Rothstein J., Bovento G., Giaume C. Plasticity of astroglial networks in the olfactory glomeruli. Proc Natl Acad Sci U S A, 108(45):18442-6 (2011)