We seek a postdoctoral scientist to reinforce our research efforts on the structural and molecular mechanisms of neural circuit plasticity in the hippocampus using super‐resolution STED microscopy in vivo, focusing on the synaptic correlates of learning and memory dysfunction. The project is part of an international collaboration formed by three leading research teams at the CNRS / University of Bordeaux (Nägerl and Choquet) and the German Center for Neurodegenerative Diseases (DZNE) in Bonn (Fuhrmann). We look for highly motivated candidates with a strong background and interest in optical microscopy and cellular neuroscience.
Initial funding is for 2 years.
Contact: Valentin Nägerl, team leader, Interdisciplinary Institute for Neuroscience (IINS) France
Project related references:
1. Bethge P, Chereau R, Avignone E, Marsicano G, Nägerl UV (2013). Two‐photon excitation STED microscopy in two colors in acute brain slices. Biophys J 104, 778‐785.
2. Tønnesen J, Katona G, Rózsa B, Nägerl UV (2014). Spine neck plasticity regulates compartmentalization of synapses. Nat Neurosci. May; 17(5): 678‐85.
3. Constals A, Penn AC, Compans B, Toulme E, Phillipat A, Marais S, Retailleau N, Hafner AS, Coussen F, Hosy E, Choquet D (2015). Glutamate‐induced AMPA receptor desensitization increases their mobility and modulates short‐term plasticity through unbinding from Stargazin. Neuron 85, 787‐803.
4. Gu L, Kleiber S, Schmid L, Nebeling F, Chamoun M, Steffen J, Wagner J, Fuhrmann M (2014). Longterm in vivo imaging of dendritic spines in the hippocampus reveals structural plasticity. J Neurosci. 34(42): 13948‐53.