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Postdoctoral research position - January 2019

3-YEAR POSTDOC POSITION AVAILABLE

A postdoctoral research position is available immediately, for up to 3 years, to study the structure and therapeutic targeting of disease-linked neuronal cell-surface protein complexes.

The project will focus on novel neuronal ligand-receptor interactions, and is an active collaboration with laboratories at the VIB & KU Leuven Center for Brain & Disease Research, Leuven, Belgium (https://cbd.vib.be/).

Recent relevant publications illustrating the methodologies include Elegheert J. et al., Neuron, 2017; Elegheert J. et al., Science, 2016, and Elegheert J. et al., Nature Protocols, 2018.

Activities

The work will involve mammalian protein production, protein chemistry, biophysical interaction analysis, X-ray crystallography, and discovery of nanobodies and antibodies.

Required skills

The candidate must hold a PhD degree and have less than two years of post-doctoral experience at the start of the contract. The candidate should have a solid background in molecular biology, biochemistry and/or structural biology. Experience with (i) mammalian expression systems (HEK293 cell lines), (ii) biophysical analysis methods (surface plasmon resonance, isothermal titration calorimetry, microscale thermophoresis, etc.), and (iii) X-ray crystallography, is preferred but not mandatory. The candidate should be highly motivated, a team player, and have a can-do problem-solving attitude.

Work context

This is a full-time position. The project will be carried out under the supervision and mentorship of Dr. Jonathan Elegheert at the IINS in Bordeaux, France, which is recognised for its expertise in molecular and cellular neuroscience, and which is further embedded within the Bordeaux Neurocampus (http://www.bordeaux-neurocampus.fr/en/index.html), a vibrant community of more than 600 neuroscientists.

Scientific environment

The IINS harbors state-of-the-art facilities for protein biochemistry, molecular biology, mammalian cell culture and animal models, as well as microscopic imaging in the on-site Bordeaux Imaging Center (BIC; http://www.bic.u-bordeaux.fr/).

The European Institute of Chemistry and Biology (IECB; http://www.iecb.u-bordeaux.fr/index.php/en) at the University of Bordeaux is in close proximity to the IINS, and our team has full access to X-ray crystallography, cryo-electron microscopy and biophysical analysis equipment.

Contact

For all inquiries, please contact;

Dr. Jonathan Elegheert
E-mail : jonathan.elegheert@u-bordeaux.fr
Tel : +33-(0)5.33.51.48.57