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Home > TEAMS > TEAM GIANNONE > PUBLICATIONS

Publications

Keys Publications

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions.
Rossier O, Octeau V, Sibarita J-B, Leduc C, Tessier B, Nair D, Gatterdam V, Destaing O, Albigès-Rizo C, Tampé R, Cognet L, Choquet D, Lounis B, Giannone G.
Nature Cell Biology. 2012. 14,1057-67.

Nanoscale segregation of branched F-actin nucleation and elongation factors determines dendritic spine protrusions.
Chazeau A., Mehidi A., Nair D., Gautier J., Leduc C., Chamma I., Kage F., Kechkar A., Thoumine O., Rottner K., Choquet D., Gautreau A., Sibarita J.B., Giannone G. (2014) EMBO J. 2014. 33, 2745-2764.

The cancer cell glycocalyx mechanically primes integrin-dependent growth and survival.
Paszek MJ, Dufort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM.
Nature. 2014. 511, 319–325.

Neurexin-1β binding to neuroligin-1 triggers the preferential recruitment of PSD-95 versus gephyrin through tyrosine phosphorylation of neuroligin-1.
Giannone G*, Mondin M*, Grillo-Bosch D, Tessier B, Saint-Michel E, Czöndör K, Sainlos M, Choquet D, Thoumine O.
Cell Reports. 2013. 27, 3(6), 1996-2007.

Dynamic super-resolution imaging of endogenous proteins on living cells at ultra-high density.
Giannone, G., Hosy, E., Levet, F., Constals, A., Schulze, K., Sobolevsky, A. I., Rosconi, M. P., Gouaux, E., Tampé, R., Choquet, D. and Cognet, L.
Biophys J. 2010. 99, 1303-1310.

Lamellipodial Actin Mechanically Links Myosin Activity with Adhesion-Site Formation.
Giannone, G., Dubin-Thaler, B. J., Rossier, O., Cai, Y., Chaga, O., Jiang, G., Beaver, W., Dobereiner, H. G., Freund, Y., Borisy, G., and Sheetz, M. P.
Cell. 2007. 128, 561-575.

All Publications

2016

Basu R., Whitlock B.M., Husson J., Le Floc’h A., Jin W., Oyler-Yaniv A., Dotiwala F., Giannone G., Hivroz C., Biais N., Lieberman J., Lance C Kam L.C., Huse M.
Cytotoxic T cells use mechanical force to potentiate target cell killing.
Cell. 2016. in press.

2015

Rossier O., and Giannone G.
The journey of integrins and partners in a complex interactions landscape studied by super-resolution microscopy and single protein tracking.
Experimental Cell Research. 2015. in press.

Giannone G.
Super-resolution links vinculin localization to function in focal adhesions.
Nature Cell Biology. 2015. 17, 845-847.

Chazeau A, Garcia M, Czöndör K, Perrais P, Tessier B, Giannone G, Thoumine O.
A mechanical coupling between N-cadherin adhesions and the F-actin flow stabilizes dendritic spines.
Mol Biol Cell. 2015. 26(5), 859-873.

2014

Paszek MJ, Dufort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM.
The cancer cell glycocalyx mechanically primes integrin-dependent growth and survival.
Nature. 2014. 511, 319–325

Chazeau A, Mehidi A, Nair D, Gautier JJ, Leduc C, Chamma I, Kage F, Kechkar A, Thoumine O, Rottner K, Sibarita JB, Giannone G.
Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.
EMBO J. 2014. 33, 2745–2764.

Hamadi A., Giannone G., Takeda K, Rondé P.
Glutamate involvement in caclcium-dependent migration of astrocytoma cells.
Cancer Cell Int. 2014. 14, 42.

2013

Giannone G*, Mondin M*, Grillo-Bosch D, Tessier B, Saint-Michel E, Czöndör K, Sainlos M, Choquet D, Thoumine O.
Neurexin-1β binding to neuroligin-1 triggers the preferential recruitment of PSD-95 versus gephyrin through tyrosine phosphorylation of neuroligin-1.
Cell Reports. 2013. 27, 3(6):1996-2007.

Nair D., Hosy E., Petersen J., Constals A., Giannone G., Choquet D., Sibarita J.B.
Super-resolution imaging reveals that AMPA receptors inside synapses are dynamically organized in nanodomains regulated by PSD95.
J Neuroscience. 2013. 33, 13204-13224.

Leduc C, Si S, Gautier J, Soto-Ribeiro M, Wehrle-Haller B, Gautreau A, Giannone G, Cognet L, Lounis B.
A highly specific gold nanoprobe for live-cell single-molecule imaging.
Nano Letters. 2013. 10, 13(4):1489-94.

Winckler P., Lartigue L., Giannone G., De Giorgi F., Ichas F., Sibarita J.B., Lounis B. and Cognet L.
Identification and super-resolution imaging of ligand-activated receptor dimers in live cells.
Sci. Rep. 2013. 3, 2387.

2012

Rossier O, Octeau V, Sibarita J-B, Leduc C, Tessier B, Nair D, Gatterdam V, Destaing O, Albigès-Rizo C, Tampé R, Cognet L, Choquet D, Lounis B, Giannone G.
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions.
Nature Cell Biology. 2012. 14: 1057-67.

Giannone G., Hosy E., Sibarita J.B., Choquet D., and Cognet L.
High-Content Super-Resolution Imaging of Live Cell by uPAINT.
Methods in Molecular Biology. 2012. 950, 95-110.

2011

Grunwald C., Schulze K., Giannone G., Cognet L., Lounis B., Choquet D., and Tampé R.
Quantum-yield-optimized fluorophores for site-specific labeling and super-resolution imaging.
Journal of the American Chemical Society . 2011. 133, 8090-8093.

Mathur, A., Roca-Cusachs, P., Rossier, O., Wind, S.J., Sheetz, M.P. & Hone, J.C.
New approach for measuring protrusive forces in cells.
J Vac Sci Technol B . 2011. 29(6), 06FA02

Rangamani, P., Fardin, M.-A., Xiong, Y., Lipshtat, A., Rossier, O., Sheetz, M.P. & Iyengar, R.
Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading.
Biophys J. 2011.100, 845-857.

2010

Giannone G, Hosy E, Levet F, Constals A, Schulze K, Sobolevsky AI , Rosconi MP, Gouaux E, Tampe R, Choquet D, Cognet L.
Dynamic Superresolution Imaging of Endogenous Proteins on Living Cells at Ultra-High Density.
Biophys J. 2010.99:1303-1310 .

Rossier O, Gauthier N, Biais N, Vonnegut W, Fardin MA, Avigan P, Heller ER, Mathur A, Ghassemi S, Koeckert MS, Hone JC, Sheetz MP.
Force generated by actomyosin contraction builds bridges between adhesive contacts.
EMBO J. 2010. 29(6):1055-68.

Fardin*, M. A., Rossier*, O. M., Rangamani, P., Avigan, P. D., Gauthier, N. C., Vonnegut, W., Mathur, A., Hone, J., Iyengar, R., and Sheetz, M. P.
Cell spreading as a hydrodynamic process.
Soft Matter. 2010. 6, 4788-4799.

Xiong, Y., Rangamani, P., Fardin, M. A., Lipshtat, A., Dubin-Thaler, B., Rossier, O., Sheetz, M. P., and Iyengar, R.
Mechanisms controlling cell size and shape during isotropic cell spreading.
Biophys J. 2010. 98, 2136-2146.

Cai, Y. F., Rossier, O., Gauthier, N. C., Biais, N., Fardin, M. A., Zhang, X., Miller, L. W., Ladoux, B., Cornish, V. W., and Sheetz, M. P.
Cytoskeletal coherence requires myosin-IIA contractility.
J Cell Sci. 2010. 123, 413-423.

2009

Giannone G, Mège RM, Thoumine O.
Multi-level molecular clutches in motile cell processes.
Trends Cell Biol. 2009. 19, 475-786.

Saint-Michel E, Giannone G, Choquet D, Thoumine O.
Neurexin/neuroligin interaction kinetics characterized by counting single cell-surface attached quantum dots.
Biophys J 97:480-489.

Ghassemi, S., Rossier, O., Sheetz, M. P., Wind, S. J., and Hone, J.
Gold-tipped elastomeric pillars for cellular mechanotransduction.
J Vac Sci Technol B. 2009. 27, 3088-3091.

Gauthier*, N. C., Rossier*, O. M., Mathur, A., Hone, J. C., and Sheetz, M. P.
Plasma Membrane Area Increases with Spread Area by Exocytosis of a GPI-anchored Protein Compartment.
Mol Biol Cell. 2009. 20, 3261-3272.

2008

Heine* M, Thoumine O*, Mondin M, Tessier B, Giannone G, Choquet D.
Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts.
PNAS. 2008. 105:20947-20952.

Thoumine O, Ewers H, Heine M, Groc L, Frischknecht R, Giannone G, Poujol C, Legros P, Lounis B, Cognet L, Choquet D.
Probing the dynamics of protein-protein interactions at neuronal contacts by optical imaging.
Chem Rev. 2008. 108:1565-1587.

Gissot, A., Di Primo, C., Bestel, I., Giannone, G., Chapuis, H., and Barthelemy, P.
Sensitive liposomes encoded with oligonucleotide amphiphiles: a biocompatible switch.
Chem Commun. 2008. 43, 5550-5552.

2007

Giannone G, Dubin-Thaler BJ, Rossier O, Cai Y, Chaga O, Jiang G, Beaver W, Dobereiner HG, Freund Y, Borisy G, Sheetz MP.
Lamellipodial actin mechanically links myosin activity with adhesion-site formation.
Cell. 2007. 128:561-575.

2006

Giannone G, Sheetz MP.
Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways.
Trends Cell Biol. 2006.16:213-223.

Dobereiner, H. G., Dubin-Thaler, B. J., Hofman, J. M., Xenias, H. S., Sims, T. N., Giannone, G., Dustin, M. L., Wiggins, C. H., and Sheetz, M. P.
Lateral membrane waves constitute a universal dynamic pattern of motile cells.
Phys Rev Lett. 2006. 97, 038102.

Cai, Y., Biais, N., Giannone, G., Tanase, M., Jiang, G., Hofman, J. M., Wiggins, C. H., Silberzan, P., Buguin, A., Ladoux, B., and Sheetz, M. P.
Nonmuscle Myosin IIA-Dependent Force Inhibits Cell Spreading and Drives F-Actin Flow.
Biophys J. 2006. 91, 3907-3920.

2005

Dobereiner, H. G., Dubin-Thaler, B. J., Giannone, G., and Sheetz, M. P.
Force sensing and generation in cell phases: analyses of complex functions.
J Appl Physiol. 2005. 98, 1542-1546.

2004

Giannone G, Dubin-Thaler BJ, Dobereiner HG, Kieffer N, Bresnick AR, Sheetz MP.
Periodic lamellipodial contractions correlate with rearward actin waves.
Cell. 2004. 116:431-443.

Dobereiner, H. G., Dubin-Thaler, B., Giannone, G., Xenias, H. S., and Sheetz, M. P. Dynamic phase transitions in cell spreading.
Phys Rev Lett. 2004. 93, 108105.

Dubin-Thaler, B. J., Giannone, G., Dobereiner, H. G., and Sheetz, M. P.
Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs.
Biophys J. 2004. 86, 1794-1806.

Giannone, G., Ronde, P., Gaire, M., Beaudouin, J., Haiech, J., Ellenberg, J., and Takeda, K.
Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions.
J Biol Chem. 2004. 279, 28715-28723.

2003

Borghi, N., Rossier, O., and Brochard-Wyart, F.
Hydrodynamic extrusion of tubes from giant vesicles.
Europhys Lett. 2003. 64, 837-843.

Rossier, O., Cuvelier, D., Borghi, N., Puech, P. H., Derenyi, I., Buguin, A., Nassoy, P., and Brochard-Wyart, F.
Giant vesicles under flows: Extrusion and retraction of tubes.
Langmuir. 2003. 19, 575-584.

Cuvelier, D., Rossier, O., Bassereau, P., and Nassoy, P.
Micropatterned "adherent/repellent" glass surfaces for studying the spreading kinetics of individual red blood cells onto protein-decorated substrates.
Eur Biophys J. 2003. 32, 342-354.

Jiang, G., Giannone, G., Critchley, D. R., Fukumoto, E., and Sheetz, M. P.
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature. 2003. 424, 334-337.

Giannone, G., Jiang, G., Sutton, D. H., Critchley, D. R., and Sheetz, M. P.
Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation.
J Cell Biol. 2003. 163, 409-419.

Martin, S., Giannone, G., Andriantsitohaina, R., and Martinez, M. C.
Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis.
Br J Pharmacol. 2003. 139, 1095-1102.

2002

Giannone, G., Ronde, P., Gaire, M., Haiech, J., and Takeda, K.
Calcium oscillations trigger focal adhesion disassembly in human U87 astrocytoma cells.
J Biol Chem. 2002. 277, 26364-26371.

Scherberich, A., Giannone, G., Perennou, E., Takeda, K.,Boucheix, C., Rubinstein, E., Lanza, F., andBeretz, A.
FAK-mediated inhibition of vascular smooth muscle cell migration by the tetraspanin CD9.
Thromb Haemost. 2002. 87, 1043-1050.

2000

Martin, A., Rossier, O., Buguin, A., Auroy, P., and Brochard-Wyart, F.
Spinodal dewetting of thin liquid films at soft interfaces.
Eur Phys J E. 2000. 3, 337-341.

Ronde, P., Giannone, G., Gerasymova, I., Stoeckel, H., Takeda, K., and Haiech, J.
Mechanism of calcium oscillations in migrating human astrocytoma cells.
Biochim Biophys Acta. 2000. 1498, 273-280.

Giannone, G., Takeda, K., and Kleschyov, A. L.
Novel activation of non-selective cationic channels by dinitrosyl iron-thiosulfate in PC12 cells.
J Physiol. 2000. 529 Pt 3, 735-745.