The team headed by Marc Landry and entitled "Mécanismes centraux de la sensibilisation à la douleur", develops 5 research axes:
1/ Role of the intrinsic properties of dorsal horn neuron (DHNs) in the plasticity of nociceptive transmission in naive ans pathological conditions. This axis is divided in 2 parts :
- I. In vivo High-Intensity-Focused-Ultrasounds(HIFU)-mediated heat induction of gene deletion. Managed by Christel Baudet, lecturer in Cell Biology.
- II Role of DHNs intrinsic properties in plasticity of nociceptive transmission. Managed by Pascal Fossat, lecturer in Biology of Organisms.
2/ The mechanisms of GABAb receptor disinhibition and consequences in pain disorders. Managed by Marc Landry Professor in Cell Biology and Rabia Bennazzouz, Research Engineer.
3/ miRNA-based regulatory system in brain disorders. Axis managed by Alexandre Favereaux, lecturer in Cell Biology.
4/ The role and function of C-LTMR sensory fibers in pain transmission and pain disorders. Yves Le Feuvre, Researcher, is in charge of this project.
5/ Role of Neuropeptides in the modulation of descending pathways controlling nociceptive transmission. managed by Pascal Fossat, Olivier Roca-Lapirot (Post-doc), and Marc Landry.