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The third ERC Advanced Grant for Daniel Choquet

The third ERC Advanced Grant for Daniel Choquet

Daniel Choquet, CNRS Senior Researcher at the Interdisciplinary Institute for Neuroscience (IINS), is for the third time recipient of an ERC Advanced Grant awarded by the European Research Council (ERC).
After Nano-Dyn-Syn in 2009, ADOS in 2014, he is distinguished for Dyn-Syn-Mem project which aims to understand the dynamics and functional roles of synaptic plasticity in memory phenomena. By combining ultra-high resolution microscopy, cell biology, physiology and behavioral approaches, this project will bring a new perspective on the cellular basis of learning.

- Project summary:

Activity-dependent plasticity of synaptic transmission together with refinement of neural circuits connectivity are between the core mechanisms and memory. While there is already extensive knowledge of the mechanisms of synaptic plasticity, the fundamental questions of molecular dynamics and the functional aspects of various forms of synaptic plasticity in information processing, learning and behavior.
We previously uncovered basic features of glutamate receptor and their role in excitatory synaptic transmission. Our new ground-breaking objectives are:
1) to uncover, in a physiological context, the dynamic mechanisms through which synapses modulate their strength in response to neuronal activity by integrating ,
2) to understand the role of these tools in the context of these procedures, and their role in the management of these functions.
For this aim, I lead a team of neurobiologists, physicists and chemists with a collaborative record of accomplishment. We will combine imaging, cellular neurobiology, physiology and behavior to probe the mechanisms and roles of different forms of synaptic plasticity.
New in tissue high-resolution imaging combined with innovative molecular reporters and electrophysiology will allow for the analysis of receptors in long-term synaptic plasticity in physiological conditions. We will probe the interplay between activity-dependent changes in synaptic strength and circuit function with new photo-activable modifications of receiver traffic with unprecedented time and space resolution. The use of these tools in vivo will allow identifying the roles of synaptic plasticity in sensory information processing and the various phases of spatial memory training.

- Contact: Daniel Choquet, daniel.choquet@u-bordeaux.fr

- See the CNRS press release in French "Bourses ERC « Advanced » : le CNRS en tête des organismes européens"
- the University news "L’Europe distingue des chercheurs bordelais"