Supervisory authorities


Presentation of the institute




5 Keys Publications

*Vergnano A, *Rebola N, *Savtchenko L, Pinheiro P, Kieffer B, Rusakov D, #Mulle C and #Paoletti P (2014).
Zinc dynamics and action at excitatory synapses. #equal senior authors
Neuron 82: 1101–1114.

Carta M*, Lanore F*, Rebola N*, Szabo Z, Viana Da Silva S, Lourenço J, Verraes A, Nadler A, Schultz C, Blanchet C, Mulle C (2014)
Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels.
Neuron 81: 787–799.

Carta, M., Opazo, P., Veran, J., Athané, A., Choquet, D., *Coussen, F., and *Mulle, C. (2013).
CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors. *Equal contribution
The EMBO Journal 32: 496–510.

Veran, J., Kumar, J., Pinheiro, P.S., Athané, A., Mayer, M.L., *Perrais, D., and *Mulle, C. (2012).
Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface. *Equal contribution
Neuron 76: 565–578.

Rebola N, Carta M, Lanore F, Blanchet C, Mulle C (2011)
NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses.
Nat Neurosci 14: 691-693.

All Publications


Maingret V, Barthet G, Deforges S, Jiang N, Mulle C, Amédée T. (2017)
PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer’s disease.
Neurobiol Aging. 50:13-24.


Zucca S, Griguoli M, Malézieux M, Grosjean N, Carta M, Mulle C. (2016)
Control of spike transfer at hippocampal mossy fiber synapses in vivo by GABAA and GABAB receptor mediated inhibition.
J Neurosci. Dec 2. 2057-16.

Fièvre S, Carta M, Chamma I, Labrousse V, Thoumine O, Mulle C. (2016)
Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells.
Nat Commun. 7:12738.

Borralleras C, Mato S, Amédée T, Matute C, Mulle C, Pérez-Jurado LA, Campuzano V (2016)
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome.
Mol Brain. 9:76.

George J, Cunha RA, Mulle C, Amédée T. (2016)
Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors.
Eur J Neurosci. 43(10):1366-1378.

Viana da Silva S, Haberl MG, Zhang P, Bethge P, Lemos C, Gonçalves N, Gorlewicz A, Malezieux M, Gonçalves FQ, Grosjean N, Blanchet C, Frick A, Nägerl UV, Cunha RA, Mulle C (2016)
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors.
Nat Commun. 7:11915.


Nadler A, Yushchenko DA, Müller R, Stein F, Feng S, Mulle C, Carta M, Schultz C (2015) Exclusive photorelease of signalling lipids at the plasma membrane.
Nat Commun. 6:10056.

Stanic J, Carta M, Eberini I, Pelucchi S, Marcello E, Genazzani AA, Racca C, Mulle C, Di Luca M, Gardoni F (2015)
Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.
Nat Commun. 6:10181.

Crépel V, Mulle C (2015)
Physiopathology of kainate receptors in epilepsy.
Curr Opin Pharmacol. 20:83-88.

*Haberl MG, *Viana da Silva S, Guest JM, Ginger M, Ghanem A, Mulle C, Oberlaender M, Conzelmann KK, Frick A. (2015)
An anterograde rabies viros vector for high-resolution large-scale reconstruction of 3D neuron morphology.
Brain Struct Funct 3:1369-1379.


Piguel NH, Fievre S, Blanc JM, Carta M, Moreau MM, Moutin E, Pinheiro VL, Medina C, Ezan J, Lasvaux L, Loll F, Durand CM, Chang K, Petralia RS, Wenthold RJ, Stephenson FA, Vuillard L, Darbon H, Perroy J, Mulle C, Montcouquiol M, Racca C, Sans N (2014)
Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling.
Cell Rep. 9(2):712-127.

Pascual-Lucas M, Viana da Silva S, Di Scala M, Garcia-Barroso C, González-Aseguinolaza G, Mulle C, Alberini CM, Cuadrado-Tejedor M, Garcia-Osta A (2014)
Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice.
EMBO Mol Med. 6(10):1246-1262.

Carta M, Fièvre S, Gorlewicz A, Mulle C (2014)
Kainate receptors in the hippocampus.
Eur J Neurosci. 39(11):1835-1844.

Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M, Chieregatti E, Mulle C, Passafaro M, Sassone J. (2014)
Parkin regulates kainate receptors by interacting with the GluK2 subunit
Nat Commun, 5:5182.

Elgoyhen AB, Swanson GT, Mulle C (2014)
Stephen F. Heinemann (1939–2014).
Neuron, 84:15-17

*Carta M, *Lanore F, *Rebola N, Szabo Z, Viana Da Silva S, Lourenço J, Verraes A, Nadler A, Schultz C, Blanchet C, Mulle C (2014)
Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels.
Neuron, 81:787-799

Micheau J, Vimeney A, Normand E, Mulle C, Riedel G. (2014)
Impaired hippocampus-dependent spatial flexibility and sociability represent autism-like phenotypes in GluK2 mice
Hippocampus 24(9):1059-1069.

*Vergnano A, *Rebola N, *Savtchenko L, Pinheiro P, Kieffer B, Rusakov D, #Mulle C and #Paoletti P (2014).
Zinc dynamics and action at excitatory synapses. #equal senior authors
Neuron 82, 1101–1114

Péret A, Christie L, Ouedrago DW, Gorlewicz A, Epsztein J, Mulle C and Crépel V (2014).
Contribution of Aberrant GluK2-containing Kainate Receptors to Chronic Seizures in Temporal Lobe Epilepsy.
Cell Report 8(2):347-54.


Pinheiro PS, Lanore F, Veran J, Artinian J, Blanchet C, Crépel V, Perrais D, Mulle C.
Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses.
Cereb Cortex. 2013 Feb;23(2):323-31

Carta M, Opazo P, Veran J, Athané A, Choquet D, Coussen F, Mulle C.
CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.
EMBO J. Jan 4. 10.1038/emboj.2012.334


Lanore F, Labrousse VF, Szabo Z, Normand E, Blanchet C, Mulle C.
Deficits in morphofunctional maturation of hippocampal mossy fiber synapses in a mouse model of intellectual disability.
J Neurosci. Dec 5;32(49):17882-93

Veran J, Kumar J, Pinheiro PS, Athané A, Mayer ML, Perrais D, Mulle C.
Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface.
Neuron. Nov 8;76(3):565-78

Gelsomino G, Menna E, Antonucci F, Rodighiero S, Riganti L, Mulle C, Benfenati F, Valtorta F, Verderio C, Matteoli M.
Kainate Induces Mobilization of Synaptic Vesicles at the Growth Cone through the Activation of Protein Kinase A.
Cereb Cortex. 2012 Mar 7

Bénard G, Massa F, Puente N, Lourenço J, Bellocchio L, Soria-Gómez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutiérrez S, Martín-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, López-Rodríguez ML, Grandes P, Rossignol R, Marsicano G.
Mitochondrial CB₁ receptors regulate neuronal energy metabolism.
Nat Neurosci. Mar 4;15(4):558-64

Caiati MD, Sivakumaran S, Lanore F, Mulle C, Richard E, Verrier D, Marsicano G, Miles R, Cherubini E.
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Sci Rep. 2:285

Santos SD, Iuliano O, Ribeiro L, Veran J, Ferreira JS, Rio P, Mulle C, Duarte CB, Carvalho AL.
Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors.
J Biol Chem. Feb 24;287(9):6868-77


Hemar A, Mulle C.
Maladie d’Alzheimer, peptide β-amyloïde et synapses [Alzheimer’s disease, amyloid peptide and synaptic dysfunction].
Med Sci (Paris) 27, 733-736

Huyghe D, Veran J, Labrousse VF, Perrais D, Mulle C, Coussen F.
Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking.
J Neurosci 31, 11645-11654

Rebola N, Carta M, Lanore F, Blanchet C, Mulle C.
NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses.
Nat Neurosci 14, 691-693

Lourenco FC, Matias I, *Marsicano G, *Mulle C.
Pharmacological activation of kainate receptors drives endocannabinoid mobilization. *equal senior authors.
J Neurosci 31, 3243-3248

*Contractor A, *Mulle C, *Swanson GT.
Kainate receptors coming of age: milestones of two decades of research. *equal contribution.
Trends Neurosci 34, 154-163


Mondin M, Carta M, Normand E, Mulle C, Coussen F.
Profilin II regulates the exocytosis of kainate glutamate receptors.
J Biol Chem 285:40060-40071

Malinverno M, Carta M, Epis R, Marcello E, Verpelli C, Cattabeni F, Sala C, Mulle C, Di Luca M, Gardoni F.
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage.
J Neurosci 30:16343-16355

Perrais D, Veran J, Mulle C.
Gating and permeation of kainate receptors: differences unveiled.
Trends Pharmacol Sci 31:516-522

Lanore F, Blanchet C, Fejtova A, Pinheiro P, Richter K, Balschun D, Gundelfinger E, Mulle C.
Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon.
J Physiol 588:2133-2145

Segerstrale M, Juuri J, Lanore F, Piepponen P, Lauri SE, Mulle C, Taira T.
High firing rate of neonatal hippocampal interneurons is caused by attenuation of afterhyperpolarizing potassium currents by tonically active kainate receptors.
J Neurosci 30:6507-6514

Lourenco J, Cannich A, Carta M, Coussen F, *Mulle C, *Marsicano G.
Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. *equal senior authors.
Nat Neurosci 13:197-204

Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Stromgaard K, Ronn LC, Gether U.
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
Proc Natl Acad Sci U S A 107:413-4

Rebola N, Srikumar BN, Mulle C.
Activity-dependent synaptic plasticity of NMDA receptors.
J Physiol 588:93-99


Vincent P, Mulle C.
Kainate receptors in epilepsy and excitotoxicity.
Neuroscience 158:309-323

Lanore F, Rebola N, Carta M.
Spike-timing-dependent plasticity induces presynaptic changes at immature hippocampal mossy fiber synapses. Journal Club.
J Neurosci 29:8299-8301

Perrais D, Coussen F, Mulle C.
Atypical functional properties of GluK3-containing kainate receptors.
J Neurosci 29:15499-15510

Perrais D, Pinheiro PS, Jane DE, Mulle C.
Antagonism of recombinant and native GluK3-containing kainate receptors.
Neuropharmacology 56:131-140

Sachidhanandam S, Blanchet C, Jeantet Y, Cho YH, Mulle C.
Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.
J Neurosci 29:5000-5008


Rebola N, Lujan R, Cunha RA, Mulle C.
Adenosine A(2A) Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses.
Neuron 57:121-134

Pinheiro PS, Mulle C.
Presynaptic glutamate receptors: physiological functions and mechanisms of action.
Nat Rev Neurosci 9:423-436

Barberis A, Sachidhanandam S, Mulle C.
GluR6/KA2 kainate receptors mediate slow-deactivating currents.
J Neurosci 28:6402-6406


Rebola N, Sachidhanandam S, Perrais D, Cunha RA, Mulle C.
Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.
J Neurosci 27:3987-3993

Pinheiro PS, Perrais D, Coussen F, Barhanin J, Bettler B, Mann JR, Malva JO, Heinemann SF, Mulle C.
GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
Proc Natl Acad Sci U S A 104:12181-12186

Pilo Boyl P, Di Nardo A, Mulle C, Sassoe-Pognetto M, Panzanelli P, Mele A, Kneussel M, Costantini V, Perlas E, Massimi M, Vara H, Giustetto M, Witke W.
Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.
EMBO J 26:2991-3002

Laezza F, Wilding TJ, Sequeira S, Coussen F, Zhang XZ, Hill-Robinson R, Mulle C, Huettner JE, Craig AM.
KRIP6: a novel BTB/kelch protein regulating function of kainate receptors.
Mol Cell Neurosci 34:539-550

Ibarretxe G, Perrais D, Jaskolski F, Vimeney A, Mulle C.
Fast regulation of axonal growth cone motility by electrical activity.
J Neurosci 27:7684-7695