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Home > TEAMS > TEAM HUMEAU > PUBLICATIONS

Publications

"If I have seen further it is by standing on the shoulders of giants"
Isaac Newton, 1676

All Publications

2017

Aincy M, Meziane H, Herault Y, Humeau Y.
Synaptic dysfunction in amygdala in intellectual disorder models. Prog Neuropsychopharmacol Biol Psychiatry 2017, 10.1016/j.pnpbp.2017.07.028.

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Penn, A C, Zhang, C L, Georges, F, Royer, L, Breillat, C, Hosy, E, Petersen, J D, Humeau, Y and Choquet, D (2017) Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature 2017, 10.1038/nature23658.

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Arbogast T, Iacono G, Chevalier C, Afinowi N, Houbaert X, van Eede M, Laliberté C, Birling MC, Selloum M, Linda K, Meziane H, Sorg T, Nadif Kasri N, Koolen D, Stunnenberg H, Henkelman M, Kopanitsa M, Humeau Y, de Vries B, Herault Y (2017). Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition, synaptic transmission and neurogenesis. PLoS Genetics 2017, 10.1371/journal.pgen.1006886

2016

Meziane H, Khelfaoui M, Morello N, Hiba B, Calcagno E, Reibel-Foisset S, Selloum M, Chelly J, Humeau Y, Riet F, Zanni G, Herault Y, Bienvenu T, Giustetto M, Billuart P.
Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.
Hum Mol Genet 2016 Jun 1;25(11):2314-2323.

2015

Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y.
Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.
Hum Mol Genet 2015 Dec 1;24(23):6736-55. doi: 10.1093/hmg/ddv380.

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Ramos-Brossier M, Montani C, Lebrun N, Gritti L, Martin C, Seminatore-Nole C, Toussaint A, Moreno S, Poirier K, Dorseuil O, Chelly J, Hackett A, Gecz J, Bieth E, Faudet A, Heron D, Frank Kooy R, Loeys B, Humeau Y, Sala C, Billuart P.
Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis.
Hum Mol Genet 2015 Feb 15;24(4):1106-18. doi: 10.1093/hmg/ddu523.

2014

Zhang, C.L.#, Houbaert X.#, Lepleux M., Deshors M., Normand E., Gambino F., Herzog E., and Humeau Y.
The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability.
Brain Structure and Function, 2014, doi: 10.1007/s00429-014-0882-x, (# equal contributors)

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Heck N., Dos Santos M., Amairi B., Salery M., Besnard A., Herzog E., Boudier T., Vanhoutte P., Caboche J.
A new automated 3D detection of synaptic contacts reveals the formation of cortico-striatal synapses upon cocaine treatment in vivo.
Brain Structure and Function, 2014, BSAF-D-14-00199R2, in press

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Jayachandran, R., Liu, X., BoseDasgupta, S., Mueller, P., Zhang, C.L., Moshous, D., Studer, V., Schneider, J., Genoud, C., Fossoud, C., Gambino, F., Khelfaoui, M., Müller, C., Bartholdi, C., Rossez, H., Stiess, M., Houbaert, X., Jaussi, R., Frey, D., Kammerer, R.A., Deupi, X., de Villartay, J.P., Lüthi, A., Humeau, Y.*, and Pieters, J*.
Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein kinase A Signaling.
PLoS Biology, 12, e1001820. (*co-corresponding authors)

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Biesemann, C., Grønborg, M., Luquet, E., Wichert, S.P., Bernard, V., Bungers, S.R., Cooper, B., Varoqueaux, F., Li, L., Byrne, .A., Urlaub, H., Jahn, O., Brose, N., Herzog, E.
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
The EMBO journal, 33: 157-170

2013

Ammar, M.R., Humeau, Y., Hanauer, A., Nieswandt, B., Bader, M.F., Vitale, N.
The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid.
J Neurosci, 33:19470-19479

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Khelfaoui M., Gambino F., Houbaert X., Ragazzon B., Müller C., Carta M., Lanore F., Srikumar B.N., Gastrein P., Lepleux M., Zhang C.L., Kneib M., Poulain B., Reibel-Foisset S., Vitale N., Chelly J., Billuart P., Lüthi A. and Humeau Y.
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signaling pathway.
Philosophical Transactions B, 369, 20130160

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Houbaert X.#, Zhang C.L.#, Gambino F., Lepleux M., Deshors M., Normand E., Levet F., Ramos M., Billuart P., Chelly J., Herzog E. and Humeau Y.
Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder.
J Neurosci. 33:13805-13819. #equal contribution

Siksou L., Silm K., Biesemann C., Nehring R.B., Wojcik S.M., Triller A., El Mestikawy, S., Marty S., Herzog E.
A role for vesicular glutamate transporter 1 in synaptic vesicle clustering and mobility.
Eur J Neurosci. 37:1631-1642

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Li D., Hérault K., Silm K., Evrard A., Wojcik S., Oheim M., Herzog E., Ropert N.
Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes.
J Neurosci. 33:4434-4455

2012

Blaise S., Kneib M., Rousseau A., Gambino F., Chenard M.P., Muckenstrum M., Alpy F., Tomasetto C., Humeau Y., Rio M.C.
In vivo evidence that TRAF4 is required for CNS myelin homeostasis and inhibits MAG-/Nogo-A-induced NgR/p75NTR/RhoA signaling pathway.
Plos One e30917

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Bianchi V.#, Gambino F.#, Muzio L., Toniolo D., Humeau Y. and D’Adamo P.
Forebrain deletion of αGDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections.
Plos One e29763. #equal contribution

2011

Humeau Y, Candiani S, Ghirardi M, Poulain B, Montarolo P.
Functional roles of synapsin: Lessons from invertebrates.
Seminars in Cell and Developmental Biology, 22: 425-433

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Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, Kirchhoff F, Brose N.
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice.
J Neurosci. 31:15544-15559

2010

Doussau F, Humeau Y, Benfenati F, Poulain B.
A novel form of presynaptic plasticity based on the fast reactivation of release sites switched off during low frequency depression.
J Neurosci. 49:16679-16691

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Gambino F, Khelfaoui M, Poulain B, Bienvenu T, Chelly J, Humeau Y.
Synaptic maturation at cortical projections to the lateral amygdala in a mouse model of Rett syndrome.
PLoS One, 5:e11399

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Pavlowsky A, Gianfelice A, Pallotto M, Zanchi A, Vara H, Khelfaoui M, Valnegri P, Rezai X, Bassani S, Brambilla D, Kumpost J, Blahos J, Roux MJ, Humeau Y, Chelly J, Passafaro M, Giustetto M, Billuart P, Sala C.
A postsynaptic Signaling Pathway that may Account for the cognitive Defect Due to IL1RAPL1 Mutation.
Current Biology, 20:103-115