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Cytoskeleton and membrane interplay in synaptic organization and transmission

Contact: Anna BRACHET

Tel. (+33)5 05 33 51 47 32

Scientific Context

The Cytoskeleton axis is integrated into the Dynamics of Synapse Organization and Function group.

This activity is headed by Anna Brachet (CR, senior researcher) and currently involves Marie-Lise Jobin (post-doctoral fellow, FRM retour) and Isabelle Seynat (assistant engineer Labex Brain). Her objective is to study the role of cytoskeleton proteins and their interactions with the membrane in the dynamic regulation of dendritic spine morphology and physiology.
This activity is currently funded by the BRAIN Labex.

Selected Publications

LTP induction triggers cholesterol redistribution activating Cdc42 and driving AMPA receptor synaptic delivery.
Brachet A, Norwood S, Brouwers JF, Palomar E, Helms JB, Dotti CG and Esteban JA. The Journal of Cell Biology 2015, Mars16;208(6):791-806. (F1000)

Tetrodotoxin-resistant voltage gated sodium channel Nav1.8 constitutively interacts with ankyrin G.
Montersino A, Brachet A, Fache MP, Angles d’Ortoli S, Liu W, Feracci G, Rueda-Boroni F, Castets F and Dargent B. The Journal of Neurochemistry 2014 June 5; 131:33-41.

Determinants of voltage-gated sodium channel clustering in neurons.
Leterrier C, Brachet A, Dargent B and Vacher H. Seminars in Cell and Developmental Biology 2011 Apr;22(2):171-7.

Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier.
Brachet A, Leterrier C, Irondelle M, Fache MP, Racine V, Sibarita JB, Choquet D, Dargent B. The Journal of Cell Biology 2010 Oct 18;191(2):383-95.

Protein kinase Casein Kinase 2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G.
Bréchet A, Fache MP, Brachet A, Ferracci G, Baude A, Irondelle M, Pereira S, Leterrier C, Dargent B. The Journal of Cell Biology 2008 Dec 15;183(6):1101-14.