Supervisory authorities


Presentation of the institute



Ingrid Chamma

Researcher (CR INSERM)
CNRS/University of Bordeaux
Interdisciplinary Institute for Neurosciences
146 Rue Léo Saignat
33077 Bordeaux
ingrid.chamma at
Phone: (+33)5 33 51 47 29

Scientific Context

- Monomeric ligands

- Super-resolution microscopy

- Role of synaptic adhesion proteins in synapse formation and function


Biophysical mechanisms underlying the membrane trafficking of synaptic adhesion molecules.
Chamma I, Sainlos M, Thoumine O.
Neuropharmacology. 2019

A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation.
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, Sainlos M, Czöndör K, Thoumine O.
Nat Commun. 2018 Sep 28;9(1):3979. doi: 10.1038/s41467-018-06220-2.

Dynamics, nanoscale organization, and function of synaptic adhesion molecules.
Chamma I, Thoumine O.
Mol Cell Neurosci. 2018 Sep;91:95-107. doi: 10.1016/j.mcn.2018.04.007. Epub 2018 Apr 17. Review.

Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin.
Chamma I, Rossier O, Giannone G, Thoumine O, Sainlos M.
Nat Protoc. 2017 Apr;12(4):748-763. doi: 10.1038/nprot.2017.010. Epub 2017 Mar 9.

Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy.
Chamma I, Levet F, Sibarita JB, Sainlos M, Thoumine O.
Neurophotonics. 2016 Oct;3(4):041810. Epub 2016 Nov 3.

Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells.
Fièvre S, Carta M, Chamma I, Labrousse V, Thoumine O, Mulle C.
Nat Commun. 2016 Sep 27;7:12738. doi: 10.1038/ncomms12738.

Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin.
Chamma I, Letellier M, Butler C, Tessier B, Lim KH, Gauthereau I, Choquet D, Sibarita JB, Park S, Sainlos M, Thoumine O.
Nat Commun. 2016 Mar 16;7:10773. doi: 10.1038/ncomms10773.

The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.
Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O’Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J.
Neuron. 2015 Aug 19;87(4):764-80. doi: 10.1016/j.neuron.2015.08.007.

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.
Chazeau A, Mehidi A, Nair D, Gautier JJ, Leduc C, Chamma I, Kage F, Kechkar A, Thoumine O, Rottner K, Choquet D, Gautreau A, Sibarita JB, Giannone G.
EMBO J. 2014 Dec 1;33(23):2745-64. doi: 10.15252/embj.201488837. Epub 2014 Oct 7.

Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
Chamma I, Heubl M, Chevy Q, Renner M, Moutkine I, Eugène E, Poncer JC, Lévi S.
J Neurosci. 2013 Sep 25;33(39):15488-503. doi: 10.1523/JNEUROSCI.5889-12.2013.

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission.
Chamma I, Chevy Q, Poncer JC, Lévi S.
Front Cell Neurosci. 2012 Feb 21;6:5. doi: 10.3389/fncel.2012.00005. eCollection 2012.

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines.
Gauvain G, Chamma I, Chevy Q, Cabezas C, Irinopoulou T, Bodrug N, Carnaud M, Lévi S, Poncer JC.
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15474-9. doi: 10.1073/pnas.1107893108.