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Intrinsic properties and descending control

Pascal Fossat is lecturer in Biology of Organisms. He is recipient of the Agregation of natural sciences in 2000. Then, he performed a PhD under the supervision of F Nagy, working on central sensitization to pain. Then he moved to a postdoc in the laboratory of S Oliet where he developed a preparation of prefrontal cortex in rats to study the role of D-serine in glutamatergic transmission. He got a tenured position in 2009 as a lecturer at Bordeaux university. He worked for few years in the lab of D. Cattaert where he developed a multidisciplinary approach to show the existence of negative emotional components in crayfish. He joined the team Landry in 2014.
This axis aims at studying the role of the intrinsic properties of Dorsal Horn Neurons (DHNs) in shaping nociceptive transmission. We are particularly interested in the role of L-type calcium channels, known to be involved in plateau potential an input/output amplification mechanism. Plateau potentials sustain short term sensitisation mechanisms reveal by windup protocols. Plateau potentials and underlying windup are thought to be crucial mechanisms for long term changes associated with chronic pain syndromes.

L-type channels in plateau potential and windup

We already demonstrated that Cav1.2 L-type calcium channels are involved in neuropathic pain (Fossat et al, 2010).
We are looking at the role of Cav1.3 subunits in windup of DHNs discharge by a coupled mathematical and biological approach.

L-type channels in the peripheral receptive field of DHNs

DHNs neurones are convergent neurones that receive inputs from the periphery through both fast and low velocity sensory fibers. This convergence reveal of peripheral receptive field (RF) for each DHN. We are interesting in the plasticity of these RFs following nociceptive stimulations and the role of intrinsic properties in shaping these RFs. We use in vivo electrophysiological approaches both patch-clamp and extracellular recordings.

Modulation of L-type calcium channels

- Role of metabotropic glutamate receptors and L-type calcium channels in the nociceptive transmission. Houda Radwani.
- Role of descending 5HT neurons on the control of intrinsic propoerties of dorsal horn neurons: consequences in pain pathway. Franck Aby.

Publications on this topic

- Cav1.2 and Cav1.3 l-type calcium channels independently control short- and long-term sensitization to pain.
Houda Radwani, Maria José Lopez Gonzalez, Daniel Cattaert, Olivier Roca-Lapirot, Errami Mohamed, Eric Dobremez, Emelía Eiríksdóttir, Ülo Langel, Alexandre Favereaux, Marc Landry, Pascal Fossat. Journal of Physiology. May 2016

- Intrinsic membrane properties of spinal dorsal horn neurones modulate nociceptive information processing in vivo.
Reali C, Fossat P, Landry M, Russo RE, Nagy F. Journal of Physiology. 2011 Jun 1;589(Pt 11):2733-43. doi: 10.1113/jphysiol.2011.207712. Epub 2011 Apr 11.

- Knockdown of L calcium channel subtypes: differential effects in neuropathic pain.
Fossat P, Dobremez E, Bouali-Benazzouz R, Favereaux A, Bertrand SS, Kilk K, Léger C, Cazalets JR, Langel U, Landry M, Nagy F. 2010 Jan 20;30(3):1073-85. doi: 10.1523/ Journal of Neuroscience.3145-09.2010.

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