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Micropatterned substrates for high content screening of synapse formation

In collaboration with the company CYTOO, we developed an original system of neuronal cultures on micro-patterned substrates coated with adhesion proteins, including neurexin1β, SynCAM, and N-cadherin for the high content screening of axonal growth and synapse differentiation (Czöndör et al., Nat Comm. 2013). We plan to apply this system for the screening of pharmaceutical coumpounds that could alter or promote synapse formation (Patent 2012). This is important in a disease-related context, given that genetic mutations in neurexins and neuroligins have been recently assocated with autism spectrum disorders.