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Deciphering mechano-biology using super-resolution microscopy - Nature Cell Biology, July 2020

Deciphering mechano-biology using super-resolution microscopy - Nature Cell Biology, July 2020

Cell stretching is amplified by active actin remodeling to deform and recruit proteins in mechano-sensitive structures
Detection and conversion of mechanical forces into biochemical signals (...)

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A new website for the Aquitaine Delegation of the CNRS

A new website for the Aquitaine Delegation of the CNRS

Find on the new Aquitaine Delegation website dedicated pages to the organization of the delegation, scientific potential, innovation, as well as an agenda and news section (...)

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Retrovirus, inflammation and psychosis: a missing link identified! - Science Advances, July 2020

Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis
Mobile genetic elements, such as human endogenous retroviruses (...)

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Presynaptic failure in Alzheimer's disease - Progress in Neurobiology, May 2020

Presynaptic failure in Alzheimer’s disease - Progress in Neurobiology, May 2020

Presynaptic failure in Alzheimer’s disease
Synaptic loss is the best correlate of cognitive deficits in Alzheimer’s disease (AD). Extensive experimental evidence also indicates alterations of (...)

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Co-organization and coactivation of AMPAR, NMDAR, and mGluR - PNAS, June 2020

Co-organization and coactivation of AMPAR, NMDAR, and mGluR - PNAS, June 2020

Nanoscale co-organization and coactivation of AMPAR, NMDAR, and mGluR at excitatory synapses
The nanoscale co-organization of neurotransmitter receptors fac-ing presynaptic release sites is a (...)

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Receptor mobility under the spotlight - Science, June 2020

Receptor mobility under the spotlight - Science, June 2020

Linking glutamate receptor movements and synapse function
Regulation of neurotransmitter receptor content at synapses is achieved through a dynamic equilibrium between biogenesis and degradation (...)

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MemTraS: A new team at IINS

MemTraS: A new team at IINS

"MemTraS - Membrane traffic at synapses" is a new team recently born at IINS. The leader, David Perrais, presents the research axis:
Our goal in the team is to study the mechanisms of synapse (...)

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Bilan INSB 2019

Bilan INSB 2019

The "Bilan" of the CNRS Institute for Biological Sciences (INSB) presents a selection of scientific news, distinctions, or special events that marked the Institute and its research staff in 2019. (...)

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Review on “AMPA receptor nanoscale dynamic organization and synaptic plasticities” in Current Opinion in Neurobiology 2020

Review on “AMPA receptor nanoscale dynamic organization and synaptic plasticities” in Current Opinion in Neurobiology 2020

AMPA receptor nanoscale dynamic organization and synaptic plasticities
The emergence of new imaging techniques and molecular tools has refreshed our understanding of the principles of synaptic (...)

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IINS restarts gradually

Since March 17th, IINS was in lockdown. Nearly all its personnel was in confinement, except for a small number of people to run at minimum the animal facility and take care of the essential (...)

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Controlling synapse differentiation with light - eLife, April 2020

Controlling synapse differentiation with light - eLife, April 2020

Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation
Neuroligins (Nlgns) are adhesion proteins mediating trans-synaptic contacts in (...)

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Astrocytes: up close & personal via STED microscopy - Nature Communications, April 2020

Astrocytes: up close & personal via STED microscopy - Nature Communications, April 2020

Structural basis of astrocytic Ca2+ signals at tripartite synapses
Astrocytic Ca2+ signals can be fast and local, supporting the idea that astrocytes have the ability to regulate single (...)

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Salivary Gland Surveillance - Science Immunology, April 2020

Salivary Gland Surveillance - Science Immunology, April 2020

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance
Pathogen sensing in tissues is critical to generating rapid immune responses. Within (...)

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COVID-19 Coronavirus pandemic: News from the French Académie des Sciences

COVID-19 Coronavirus pandemic: News from the French Académie des Sciences

The Academy of Sciences provides links to find reliable information on the COVID-19 Coronavirus epidemic
For reliable information on the COVID-19 Coronavirus epidemic, the French Academy of (...)

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IINS is temporarily closed

IINS is temporarily closed

As everywhere in the world, our Lab has closed down to allow most of the personnel to go under efficient confinement and protection. Thankfully, a handful of dedicated personnel is taking care (...)

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A discrete presynaptic vesicle cycle for neuromodulator receptors - Neuron, December 2019

A major function of GPCRs is to inhibit presynaptic neurotransmitter release, requiring ligand-activated receptors to couple locally to effectors at terminals. The current understanding of how (...)

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VGLUT1 regulates synaptic-vesicle spontaneous release - eLife November 2019

A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency
“Should I stay or should I go” may summarize the mechanisms at play acting on synaptic vesicles (...)

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Post-doctoral position in dopamine synapse cell biology - November 2019

We are seeking to recruit as soon as possible a post-doctoral fellow expert in cell biology, fluorescence imaging and/or proteomics to study the heterogeneity of central synapses.
The project (...)

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How to square super-resolution microscopy? - Nature Methods, October 2019

How to square super-resolution microscopy? - Nature Methods, October 2019

A super-resolution platform for correlative live single-molecule imaging and STED microscopy
Super-resolution microscopy offers tremendous opportunities to unravel the complex and dynamic (...)

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Multivalent interactions for the recruitment of dynamin to forming vesicles - Nature Communications, Oct. 2019

Multivalent interactions for the recruitment of dynamin to forming vesicles - Nature Communications, Oct. 2019

Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
Endocytosis, the formation of vesicles from the plasma membrane, is an essential process in cells. It (...)

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