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Neuron - Feb. 2015 AMPA receptor conformation and mobility

Glutamate-Induced AMPA Receptor Desensitization Increases Their Mobility and Modulates Short-Term Plasticity through Unbinding from Stargazin
Neuron 85, 1–17, February 18, 2015 >

Glutamate receptor conformation regulates their mobility to fine tune synaptic transmission.
AMPA receptors are tetrameric ion channels gated by glutamate that mediate the majority of excitatory neurotransmission. Their mobility was discovered in Bordeaux more than a decade ago and postulated to tune frequency dependent synaptic transmission. However, how could AMPA receptors exchange within tens of milliseconds in front of glutamate release sites has remained mysterious and intrigued physiologists in the last years. This study now provides a molecular mechanism to explain the interplay between AMPA receptor dynamic organization, activation and synaptic transmission. In a multidisciplinary approach associating many of the members of the team “Dynamic Organization of Synapses” at the Interdisciplinary Institute for Neuroscience, Daniel Choquet and Eric Hosy have co-supervised a study combining superresolution imaging, cell biology, biochemistry and electrophysiology to unravel the impact of AMPA receptor conformation on their surface trafficking

Audrey Constals, Andrew C. Penn, Benjamin Compans, Estelle Toulmé, Amandine Phillipat, Sébastien Marais, Natacha Retailleau, Anne-Sophie Hafner, Françoise Coussen, Eric Hosy, Daniel Choquet

Eric Hosy ,Daniel Choquet

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