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Receptor mobility under the spotlight - Science, June 2020

Receptor mobility under the spotlight - Science, June 2020

Linking glutamate receptor movements and synapse function

Regulation of neurotransmitter receptor content at synapses is achieved through a dynamic equilibrium between biogenesis and degradation pathways, receptor stabilization at synaptic sites, and receptor trafficking in and out synapses. In the past 20 years, the movements of receptors to and from synapses have emerged as a series of highly regulated processes that mediate postsynaptic plasticity. Our understanding of the properties and roles of receptor movements has benefited from technological advances in receptor labeling and tracking capacities, as well as from new methods to interfere with their movements. Focusing on two key glutamatergic receptors, we review here our latest understanding of the characteristics of receptor movements and their role in tuning the efficacy of synaptic transmission in health and brain disease.

Neurotransmitter receptors undergo a variety of large- and small-scale movements. Movements of large amplitude constantly reshuffle the receptor distribution (e.g., surface diffusion and intracellular transport). Movements at interfaces (e.g., between synaptic and extrasynaptic sites, between intracellular and surface compartments) are of small amplitude but have huge functional impacts. Each of these movements is highly regulated and finely tuned in physiological and pathological conditions.

Authors: Laurent Groc and Daniel Choquet

- Review Science 368, eaay4631, June 2020 - Doi: 10.1126/ science.aay4631
- Contacts: Laurent Groc, Daniel Choquet

+ Cf. PDF version.
+ Cf Bordeaux Neurocampus website here
+ Cf. INSB info-press (in French), here