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Review on “AMPA receptor nanoscale dynamic organization and synaptic plasticities” in Current Opinion in Neurobiology 2020

Review on “AMPA receptor nanoscale dynamic organization and synaptic plasticities” in Current Opinion in Neurobiology 2020


AMPA receptor nanoscale dynamic organization and synaptic plasticities

The emergence of new imaging techniques and molecular tools has refreshed our understanding of the principles of synaptic transmission and plasticity. Superresolution imaging and biosensors for measuring enzymatic activities in live neurons or neurotransmitter levels in the synaptic cleft are giving us an unprecedented integrated and nanoscale view on synaptic function. Excitatory synapses are now conceptualized as organized in subdomains, enriched with specific scaffolding proteins and glutamate receptors, molecularly organized with respect to the pre-synaptic source of glutamate.

This new vision of basic synaptic transmission changes our understanding of the molecular modifications which sustain synaptic plasticities. Long-term potentiation can no longer be explained simply by an increase in receptor content at the synapse. We review here the latest data on the role of nanoscale and dynamic organization of AMPA type glutamate receptors on synaptic transmission at both basal state and during short and long-term plasticities.

Nanoscale organization of pre and postsynaptic complexes. Upper left inset is a zoom on the presynaptic release machinery, trans-synaptic organization via neurexin/ neuroligin adhesion proteins and post-synaptic AMPAR nanodomains and their cluster of scaffolding proteins. Upper right inset represents in color code the modeling based concentration of glutamate reached at the post-synapse following single vesicle release. Dash lines represent at the scale the size of AMPAR nanodomains (grey) and PSD (dark). Images on the right show single color d-STORM AMPAR organization (upper), the inhomogeneity of the density inside the synapse clearly appears on the density color coded image.



- Current Opinion in Neurobiology - Volume 63, August 2020, Pages 137-145
https://doi.org/10.1016/j.conb.2020.04.003

- Contacts: Daniel Choquet and Eric Hosy