{"id":460,"date":"2025-08-26T07:58:23","date_gmt":"2025-08-26T05:58:23","guid":{"rendered":"https:\/\/www.iins.u-bordeaux.fr\/en\/events\/thesis-defense-tomas-garnier-artinano\/"},"modified":"2025-11-06T16:50:29","modified_gmt":"2025-11-06T16:50:29","slug":"thesis-defense-tomas-garnier-artinano","status":"publish","type":"buni_events","link":"https:\/\/www.iins.u-bordeaux.fr\/en\/events\/thesis-defense-tomas-garnier-artinano\/","title":{"rendered":"<span> Thesis defense &#8211; <\/span> Tom\u00e1s Garnier Arti\u00f1ano"},"content":{"rendered":"<p><strong>Venue : CARF<\/strong><\/p>\n<p>Defense in English<\/p>\n<hr \/>\n<p><strong>Tom\u00e1s Garnier Arti\u00f1ano<\/strong><\/p>\n<p>Team :\u00a0<a href=\"\/?p=124338\">Neural Basis of Perception<\/a><br \/>\nIINS<\/p>\n<h3>Title<\/h3>\n<p>Characterisation of the spatiotemporal organisation of cholinergic input in the somatosensory cortex during tactile detection<\/p>\n<h3>Abstract<\/h3>\n<p>Understanding how the brain detects sensory inputs is a key challenge in neuroscience. Brain states exert a powerful and dynamic influence over the perception of sensory stimuli, with neuromodulatory systems playing a crucial role in regulating these states. The perceptual threshold, defined as the lowest stimulus intensity detectable half the time, varies with context, behavioural state, experience, and mood. However, the mechanisms controlling this threshold remain largely unknown.<\/p>\n<p>Previous studies have demonstrated that cholinergic inputs modulate cortical activity, influencing the detection of sensory stimuli. Traditionally, neuromodulation was thought to have a widespread and uniform impact throughout the brain. However, anatomical evidence suggests that basal forebrain cholinergic neurons offer targeted innervation, potentially enabling localised modulation. There is limited evidence regarding the dynamics of cortical cholinergic modulation and its relevance to sensory perception.<\/p>\n<p>In my thesis, I characterise the spatiotemporal organisation of cholinergic activity in the somatosensory cortex (S1) of mice engaged in tactile detection, by employing a whisker-based tactile detection task. I tested the role of S1 cholinergic activity in the mouse&#8217;s sensitivity to detect tactile stimuli showing how the activity patterns of this neuromodulator change behaviour.<\/p>\n<h3>Key words<\/h3>\n<p>Perception, Touch, Somatosensory Cortex, Cholinergic Input, Spatio-temporal dynamics<\/p>\n<h3>Publication<\/h3>\n<p><a href=\"https:\/\/www.frontiersin.org\/journals\/computational-neuroscience\/articles\/10.3389\/fncom.2023.1011814\/full\">https:\/\/www.frontiersin.org\/journals\/computational-neuroscience\/articles\/10.3389\/fncom.2023.1011814\/full<\/a><\/p>\n<h3>Jury<\/h3>\n<p>President\/Chair:<br \/>\nShauna Parkes<\/p>\n<p>Raptors\/Reviewer:<br \/>\nValerie Ego-Stengel<br \/>\nBelen Pardi<\/p>\n<p>Examiner:<br \/>\nIsabelle Ferezou (to be confirmed)<br \/>\nYaroslav Sych<\/p>\n<p>Guests :<br \/>\nNaoya Takahashi<br \/>\nGr\u00e9gory Barri\u00e8re<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Characterisation of the spatiotemporal organisation of cholinergic input in the somatosensory cortex during tactile detection \/\/ Venue : CARF<\/p>\n","protected":false},"template":"","categories":[],"class_list":["post-460","buni_events","type-buni_events","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/buni_events\/460","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/buni_events"}],"about":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/types\/buni_events"}],"wp:attachment":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/media?parent=460"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/categories?post=460"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}