{"id":658,"date":"2025-11-10T11:12:48","date_gmt":"2025-11-10T10:12:48","guid":{"rendered":""},"modified":"2025-11-10T11:12:48","modified_gmt":"2025-11-10T10:12:48","slug":"seminar-gian-carlo-bellenchi","status":"publish","type":"buni_events","link":"https:\/\/www.iins.u-bordeaux.fr\/en\/events\/seminar-gian-carlo-bellenchi\/","title":{"rendered":"Seminar &#8211; Gian-Carlo Bellenchi"},"content":{"rendered":"<p><strong>Venue: Centre Broca<\/strong><\/p>\n<hr \/>\n<p><strong><a href=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2025\/11\/Bellenchi-r.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright  wp-image-189483\" src=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2025\/11\/Bellenchi-r-360x360.jpg\" alt=\"\" width=\"245\" height=\"245\" \/><\/a>Gian-Carlo Bellenchi<\/strong><br \/>\nInstitute of Biochemistry and Cell Biology IBBC-CNR,<br \/>\nMonterotondo, Rome, Italy.<br \/>\nSanta Lucia Foundation IRCCS, Rome, Italy.<\/p>\n<p>Invited by Etienne Herzog (IINS)<\/p>\n<h3>Title<\/h3>\n<p>The Contribution of microRNAs to the Development and Function of Dopaminergic Neurons<\/p>\n<h3>Abstract<\/h3>\n<p>The development and function of midbrain dopaminergic neurons (DAn) rely on tightly coordinated molecular programs involving both transcriptional and post-transcriptional regulation. While morphogens and transcription factors are well-established drivers of DAn specification, the contribution of microRNAs (miRNAs) to these processes has only recently begun to emerge. Using paired miRNA\u2013mRNA profiling during dopaminergic differentiation, we identified miR-34b\/c and miR-218 as key post-transcriptional regulators shaping DAn identity and function. miR-34b\/c promotes dopaminergic lineage commitment and differentiation during embryonic development, at least in part through modulation of Wnt1 signaling. In parallel, miR-218 facilitates the functional maturation of DAn, and its conditional deletion alters the expression of synaptic-related transcripts, disrupts intrinsic excitability, and reduces stimulus-evoked dopamine release. Together, these findings highlight miRNA\u2013mRNA co-regulatory networks as integral components of dopaminergic neuron development and physiology, and position miRNAs as essential hubs orchestrating dopaminergic differentiation and neurotransmission.<\/p>\n<h3>Related Articles<\/h3>\n<p>Pulcrano S, et al. miR-218 Regulates the Excitability of VTA Dopamine Neurons and the Mesoaccumbens Pathway in Mice. Brain Sci. 2025<\/p>\n<p>Taylor SR, et al. MicroRNA-218 instructs proper assembly of hippocampal networks. Elife. 2023<\/p>\n<p>Pulcrano S, et al. miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network. J Neurosci. 2023<\/p>\n<p>Pulcrano S, et al. \u00a0Lmx1a-Dependent Activation of miR-204\/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. Int J Mol Sci. 2022<\/p>\n<p>De Gregorio R, et al. miR-34b\/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation. Stem Cell Reports. 2018<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Venue: Centre Broca Invited by Etienne Herzog (IINS)<\/p>\n","protected":false},"template":"","categories":[],"class_list":["post-658","buni_events","type-buni_events","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/buni_events\/658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/buni_events"}],"about":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/types\/buni_events"}],"wp:attachment":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/media?parent=658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/categories?post=658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}