{"id":661,"date":"2025-11-13T09:16:25","date_gmt":"2025-11-13T08:16:25","guid":{"rendered":""},"modified":"2025-11-13T09:16:25","modified_gmt":"2025-11-13T08:16:25","slug":"thsesis-defense-simon-lecomte","status":"publish","type":"buni_events","link":"https:\/\/www.iins.u-bordeaux.fr\/en\/events\/thsesis-defense-simon-lecomte\/","title":{"rendered":"<span>Thsesis defense &#8211; <\/span>Simon Lecomte"},"content":{"rendered":"<p><strong>Venue: BBS<\/strong><\/p>\n<hr \/>\n<p><strong><a href=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2021\/10\/simon-lecomte-iins.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-186574\" src=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2021\/10\/simon-lecomte-iins-240x360.jpg\" alt=\"\" width=\"240\" height=\"360\" \/><\/a><a href=\"\/?p=140656\">Simon Lecomte<\/a><br \/>\nTeam: <\/strong><a href=\"\/?p=56873\">Synapses et circuits neuronaux<\/a><\/p>\n<p>Thesis supervisor: <a href=\"\/?p=79924\">Christophe Mulle<\/a><\/p>\n<h3>Title<\/h3>\n<p><em>&#8220;Impact of FMRP deletion on presynaptic mechanisms at mf-CA3 synapse&#8221;<\/em><\/p>\n<h3>Abstract<\/h3>\n<p>Fragile X syndrome (FXS), the most common inherited form of intellectual disability and a major cause of autism spectrum disorder, results from silencing of the Fmr1 gene encoding the RNA-binding protein, FMRP. While most research has focused on dendritic and postsynaptic mechanisms, emerging evidence suggests a presynaptic role of FMRP, particularly through cAMP-dependent signaling pathways. This project investigates how loss of FMRP affects presynaptic mechanisms in the CA3 region of the hippocampus, with a specific emphasis on cAMP\u2013protein kinase A (PKA) signaling. Using patch-clamp electrophysiology and imaging in acute and fixed mouse hippocampal slices with targeted genetic mutations in dentate gyrus cells, I show that presynaptic loss of FMRP disrupts mossy fiber\u2013CA3 synaptic transmission. My results indicate a deregulation of cAMP\u2013PKA signaling and altered presynaptic calcium-dependent mechanisms, providing new insights into the presynaptic contribution of FMRP to synaptic function in FXS.<\/p>\n<p><strong>Keywords:<\/strong> FMRP, hippocampus, mossy fiber, presynapse, patch-clamp<\/p>\n<h3>Publication<\/h3>\n<div>Marneffe, C., Moreira-de-S\u00e1, A., Lecomte, S., Erhardt, A., &amp; Mulle, C. (2025). Short term plasticity at hippocampal mossy fiber synapses. Neuroscience, <span id=\"OBJ_PREFIX_DWT363_com_zimbra_phone\" class=\"Object\" role=\"link\"><a href=\"callto:578, 105-117\">578, 105-117<\/a><\/span>. (ainsi que diverses publications dans le journal \u00e9tudiant brainstorm, et podcast &#8220;Th\u00e8se et vous&#8221;)<\/div>\n<h3>Jury<\/h3>\n<ul>\n<li>Andreas Frick (Neurocentre Magendie, Bordeaux, pr\u00e9sident du jury, examinateur)<\/li>\n<li>Ingrid Bureau (INMED, Marseille, rapportrice)<\/li>\n<li>Pierre Vincent (IGF, Montpellier, rapporteur)<\/li>\n<li>Joana Louren\u00e7o (ICM, Paris, examinatrice)<\/li>\n<li>Yann Humeau (FMI, B\u00e2le, invit\u00e9)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Impact of FMRP deletion on presynaptic mechanisms at mf-CA3 synapse \/\/ Lieu : BBS<\/p>\n","protected":false},"template":"","categories":[],"class_list":["post-661","buni_events","type-buni_events","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/buni_events\/661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/buni_events"}],"about":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/types\/buni_events"}],"wp:attachment":[{"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/media?parent=661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iins.u-bordeaux.fr\/en\/wp-json\/wp\/v2\/categories?post=661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}