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All Publications


Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion.
Mehidi A, Rossier O, Schaks M, Chazeau A, Binamé F, Remorino A, Coppey M, Karatas Z, Sibarita JB, Rottner K, Moreau V, Giannone G.
Curr Biol. 2019; pii: S0960-9822(19)30880-2.

A tessellation-based colocalization analysis approach for single-molecule localization microscopy.
Levet F, Julien G, Galland R, Butler C, Beghin A, Chazeau A, Hoess P, Ries J, Giannone G, Sibarita JB.
Nature Communications 2019; Article number: 2379.

Super-resolution fight club: assessment of 2D and 3D single-molecule localization microscopy software.
Sage D, Pham TA, Babcock H, Lukes T, Pengo T, Chao J, Velmurugan R, Herbert A, Agrawal A, Colabrese S, Wheeler A, Archetti A, Rieger B, Ober R, Hagen GM, Sibarita JB, Ries J, Henriques R, Unser M, Holden S.
Nat Methods 2019; 16(5):387-395.

Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites.
Letellier M, Levet F, Thoumine O, Goda Y.
PLoS Biology 2019;17(6): e2006223.


Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses.
Kellermayer B, Ferreira JS, Dupuis J, Levet F, Grillo-Bosch D, Bard L, Linarès-Loyez J, Bouchet D, Choquet D, Rusakov DA, Bon P, Sibarita JB, Cognet L, Sainlos M, Carvalho AL, Groc L.
Neuron 2018; 100(1); 106-119.

Bacterial cell wall nanoimaging by autoblinking microscopy.
Floc’h K, Lacroix F, Barbieri L, Servant P, Galland R, Butler C, Sibarita JB, Bourgeois D, Timmins J.
Scientific Reports 2018; 8(1).

Catalytic activation of β-arrestin by GPCRs.
Eichel K, Jullié D, Barsi-Rhyne B, Latorraca NR, Masureel M, Sibarita JB, Dror RO, von Zastrow M.
Nature 2018; 557(7705); 381-386.

Phosphatidylserine and GTPase activation control Cdc42 nanoclustering to counter dissipative diffusion.
Sartorel E, Ünlü C, Jose M, Massoni-Laporte A, Meca J, Sibarita JB, McCusker D.
Molecular Biology of the Cell 2018; 29(11); 1299-1310.

Force-dependent binding of vinculin to α-catenin regulates cell-cell contact stability and collective cell behavior.
Seddiki R, Narayana GHNS, Strale PO, Balcioglu HE, Peyret G, Yao M, Le AP, Teck Lim C, Yan J, Ladoux B, Mège RM.
Molecular Biology of the Cell 2018; 29(4); 380-388.


3D Protein dynamics in the cell nucleus.
Singh, A. P., Galland, R., Finch-edmondson, M. L., Grenci, G., Sibarita, J.B., Studer, V., Viasnoff, V., Saunders, T.
Biophysical Journal 2017; 112; 133-142.

How cells respond to environmental cues - insights from bio-functionalized substrates.
Ruprecht, V., Monzo, P., Ravasio, A., Yue, Z., Makhija, E., Strale, P.O., Gauthier, N., Shivashankar, G.V., Studer, V., Albiges-Rizo, C., Viasnoff, V.
J Cell Sci 2017; 130 (1); 51-61.

Localization-based super-resolution imaging meets high-content screening.
Beghin, A., Kechkar, A., Butler, C., Levet, F., Cabillic, M., Rossier, O., Giannone, G., Galland, R., Choquet, D., Sibarita, J.B.
Nature Methods 2017; Advanced Online Publication.

Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging.
Lukeš, T., Glatzová, D., Kvíčalová, Z., Levet, F., Benda, A., Letschert, S., Sauer, M., Brdička, T., Lasser, T., Cebecauer, M.
Nature Communications 2017; 8 (1); 1731.

A phenomenological model of cell-cell adhesion mediated by cadherins.
Mancini S, Mège RM, Sarels B, Strale PO.
Journal of Mathematical Biology 2017; 74(7); 1657-1678.


Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy.
Chamma, I., Levet, F., Sibarita, J.B., Sainlos, M., Thoumine, O.
Neurophotonics 2016; 3 (4).

Hunting Down HIV-1 Gag Proteins at the Plasma Membrane of Human T Lymphocytes.
Mariani-Floderer, C., Sibarita, J.B., Favard, C., Muriaux, D.M.
AIDS Res Hum Retroviruses 2016; 33 (7); 658-9.

Single-particle tracking uncovers dynamics of glutamate-induced retrograde transport of NF-κB p65 in living neurons.
Widera., D., Klenke, C., Nair, D., Heidbreder, M., Malkusch, S., Sibarita, J.B., Choquet, D., Kaltschmidt, B., Heilemann, M., Kaltschmidt, C.
Neurophotonics 2016; 3 (4).

Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin.
Chamma, I., Letellier, M., Butler, C., Tessier, B., Lim, K.H., Gauthereau, I., Choquet, D., Sibarita, J.B., Park, S., Sainlos, M., Thoumine, O.
Nat Commun. 2016.

Multiprotein Printing by Light-Induced Molecular Adsorption.
Strale, P.O., Azioune, A., Bugnicourt, G., Lecomte, Y., Chahid, M., Studer, V.
Adv Mater. 2016; 28 (10); 2024-9.


SR-Tesseler: a method to segment and quantify localization-based super-resolution microscopy data.
Levet, F., Hosy, E., Kechkar, A., Butler, C., Beghin, A., Choquet, C., Sibarita, J.B.
Nature Methods 2015; 12 (11); 1065-1071.

Two-tiered coupling between flowing actin and immobilized N-cadherin/catenin complexes in neuronal growth cones.
Garcia, M., Leduc, C., Lagardère, M., Argento, A., Sibarita, J.B., Thoumine, O.
Proc Natl Acad Sci USA 2015; 112 (22); 6997-7002.

3D high- and super-resolution imaging using single-objective SPIM.
Galland, R., Grenci, G., Aravind, A., Viasnoff, V.*, Studer, V.*, Sibarita, J.B.*
Nature Methods 2015; 12 (7); 641-644.
* Contributed equally to this work

A quantitative imaging-based screen reveals the exocyst as a network hub connecting endocytosis and exocytosis.
Jose, M., Tollis, S., Nair, D., Mitteau, R., Velours, C., Massoni-Laporte, A., Royou, A., Sibarita, J.B., McCusker, D.
Mol Biol Cell. 2015; 26 (13); 2519-34.

Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons.
Dupin, I., Lokmane, L., Dahan, M., Garel, S., Studer, V.
Neural Dev. 2015; 10 (5).


Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a.
Wang, T., Martin, S., Papadopulos, A., Harper, C.B., Mavlyutov, T.A., Niranjan, D., Glass, N.R., Cooper-White, J.J., Sibarita, J.B., Choquet, D., Davletov, B., Meunier, F.A.
J Neurosci. 2014; 35 (15); 6179-94.

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.
Chazeau. A., Mehidi A., Nair D., Gautier J.J., Leduc C., Chamma I., Kage F., Kechkar A., Thoumine O., Rottner K., Choquet D., Gautreau A., Sibarita J.B., Giannone G.
EMBO J. 2014;33;2745-2764.

Organization and dynamics of AMPA receptors inside synapses-nano-organization of AMPA receptors and main synaptic scaffolding proteins revealed by super-resolution imaging.
Hosy, E., Butler, C., Sibarita, J.B.
Curr Opin Chem Biol 2014; 20; 120-6.

Synaptic Control of Secretory Trafficking in Dendrites.
Hanus, C., Kochen, L., Tom Dieck, S., Racine, V., Sibarita, J.B., Schuman, E.M., and Ehlers, M.D.
Cell reports. 2014

Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Petrini, E.M., Ravasenga, T., Hausrat, T.J., Iurilli, G., Olcese, U., Racine, V., Sibarita, J.B., Jacob, T.C., Moss, S.J., Benfenati, F., et al.
Nature communications. 2014;5;3921.

High-density single-particle tracking: quantifying molecule organization and dynamics at the nanoscale.
Sibarita, J.B.
Histochem Cell Biol. 2014; 141 (6); 587-95.

Imaging of molecular surface dynamics in brain slices using single-particle tracking.
Biermann, B., Sokoll, S., Klueva, J., Missler, M., Wiegert, J.S., Sibarita, J.B., and Heine, M.
Nature communications. 2014;5;3024

Frequency of cocaine self-administration influences drug seeking in the rat: optogenetic evidence for a role of the Prelimbic cortex
Martín-García, E., Courtin, J., Renault, P., Fiancette, J.F., Wurtz, H., Simonnet, A., Levet, F., Herry, C., and Deroche-Gamonet V.
Neuropsychopharmacology. 2014;39;2317-30


Identification and super-resolution imaging of ligand-activated receptor dimers in live cells.
Winckler, P., Lartigue, L., Giannone, G., De Giorgi, F., Ichas, F., Sibarita, J.B., Lounis, B., and Cognet, L.
Scientific reports. 2013;3;2387.

mSYD1A, a Mammalian Synapse-Defective-1 Protein, Regulates Synaptogenic Signaling and Vesicle Docking.
Wentzel, C., Sommer, J.E., Nair, R., Stiefvater, A., Sibarita, J.B., and Scheiffele, P.
Neuron. 2013;78;1012-1023

Robust polarity establishment occurs via an endocytosis-based cortical corralling mechanism.
Jose, M., Tollis, S., Nair, D., Sibarita, J.B., and McCusker, D.
J Cell Biol. 2013;200;407-418

Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder.
Houbaert, X., Zhang, C.L., Gambino, F., Lepleux, M., Deshors, M., Normand, E., Levet, F., Ramos, M., Billuart, P., Chelly, J., et al.
J Neurosci. 2013;33;13805-13819

C11ORF24 Is a Novel Type I Membrane Protein That Cycles between the Golgi Apparatus and the Plasma Membrane in Rab6-Positive Vesicles.
Fraisier, V., Kasri, A., Miserey-Lenkei, S., Sibarita, J.B., Nair, D., Mayeux, A., Bardin, S., Toyoda, Y., Poser, I., Poznyakovskiy, A., et al.
PloS One. 2013;8;e82223

High-Content Super-Resolution Imaging of Live Cell by uPAINT.
Giannone, G., Hosy, E., Sibarita, JB., Choquet, D., Cognet, L.
Methods Mol Biol. 2013;950:95-110.


Targeting, resolving and quantifying cellular structures by single-molecule localization microscopy.
Sibarita, JB., Heilemann, M.
EMBO. 2012;Rep 30;13(12):1043-5.

Amplification and temporal filtering during gradient sensing by nerve growth cones probed with a microfluidic assay.
Morel, M., Shynkar, V., Galas, JC., Dupin, I., Bouzigues, C., Studer, V., Dahan, M.
Biophysical journal. 2012;103(8);1648-1656.

Heterogeneity of AMPA receptor trafficking and molecular interactions revealed by superresolution analysis of live cell imaging.
Hoze, N., Nair, D., Hosy, E., Sieben, C., Manley, S., Herrmann, A., Sibarita, JB., Choquet, D., Holcman, D.
Proc Natl Acad Sci USA. 2012;16;109(42);17052-7.

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions.
Rossier, O., Octeau, V., Sibarita, JB., Leduc, C., Tessier, B., Nair, D., Gatterdam, V., Destaing, O., Albigès-Rizo, C., Tampé, R., Cognet, L., Choquet, D., Lounis, B., Giannone, G.
Nature Cell Biology. 2012;14(10);1057-67.

TNF-α influences the lateral dynamics of TNF receptor I in living cells.
Heidbreder, M., Zander, C., Malkusch, S., Widera, D., Kaltschmidt, B., Kaltschmidt, C., Nair, D., Choquet, D., Sibarita, JB., Heilemann, M.
Biochim Biophys Acta. 2012;1823(10);1984-9.

Engineering the surface properties of microfluidic stickers.
Levache, B., Azioune, A., Bourrel, M., Studer, V., Bartolo, D.
Lab on a chip. 2012;12(17);3028-3031.

Compressive Fluorescence Microscopy for Biological and Hyperspectral Imaging.
Studer, V., Bobin, J., Chahid, M., Candes, E., Dahan, M.
PNAS. 2012;109(26);1679-1687.

A unified quantitative model of AMPA receptor trafficking at synapses.
Czöndör, K., Mondin, M., Garcia, M., Heine, M., Frischknecht, R., Choquet, D., Sibarita, JB., Thoumine, O.
PNAS. 2012;28;109(9);3522-7.

Wavelet analysis for single molecule localization microscopy.
Izeddin, I., Boulanger, J., Racine, V., Specht, CG., Kechkar, A., Nair, D., Triller, A., Choquet, D., Dahan, M., Sibarita, JB.
Optics Express. 30;20(3);2081-95.

Automatic non-parametric capsid segmentation using wavelets transform and graph.
Levet, F., Cassany, A., Kann, M., Sibarita, JB.
IEEE International Symposium on Biomedical Imaging. May 2012;.1369-72

Concentration Landscape Generators for Shear Free Dynamical Chemical Stimulation.
Morel, M., Galas, JC., Dahan, M., Studer, V.
Lab on a Chip. 2012;7;12(7);1340-6.


Robust Method for High Throughput Surface Patterning of Deformable Substrates.
Azioune, A., Carpi, N., Fink, J., Chehimi, MM., Cuvelier, D., Piel, M.
Langmuir. 2011;27;7349-7352.

Nucleus positioning: Mechanisms and functions.
Dupin, I., Etienne-Manneville, S.
Intl J Biochem Cell Bio. 2011;43;1698-707.

Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus.
Dupin, I., Sakamoto, Y., Etienne-Manneville, S.
J Cell Science. 2011;124;865-72.

External forces control mitotic spindle positioning.
Fink, J., Carpi, N., Betz, T., Bétard, A., Chebah, M., Azioune, A., Bornens, M., Piel, M.
Nature Cell Biology. 2011;13;771-778.

A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels.
Quingzong, T., Wang, I., Duchemin-Pelletier, E., Azioune, A., Carpi, N., Gao, J., Filhol, O., Piel, M., Théry, M., Balland, M.
Lab Chip. 2011;11(13);2231-2240.

Analysis of gene expression at the single-cell level using microdroplet-based microfluidic technology.
Mary, P., Dauphinot, L., Bois, N., Potier, MC., Studer, V., Tabeling, P.
Biomicrofluidics. 2011;5(2);24109

Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds.
Mondin, M., Labrousse, V., Hosy, E., Heine, M., Tessier, B., Levet, F., Poujol, C., Blanchet, C., Choquet, D., Thoumine, O.
J Neurosci. 2011;31(38);13500-13515.

Photopatterning of ultrathin electrochemiluminescent redox hydrogel films.
Milutinovic, M., Suraniti, E., Studer, V., Mano, N., Manojlovic, D., Sojic, N.
Chemical Communications. 2011;47;9125-9127.

Fast and Easy Enzyme Immobilization by Photoinitiated Polymerization for Efficient Bioelectrochemical Devices.
Suraniti, E., Studer, V., Sojic, N., Mano, N.
Analytical Chemistry. 2011;83;2824-2828.


Enhanced isochoric heating from fast electrons produced by high-contrast, relativistic-intensity laser pulses.
Perez, F., Gremillet, L., Koenig, M., Baton, SD., Audebert, P., Chahid, M., Rousseaux, C., Drouin, M., Lefebvre, E., Vinci, T., Rassuchine, J., Cowan, T., Gaillard, SA., Flippo, KA., Shepherd, R.
Physical review letters. 2010;104;085001.

Protein micropatterns: a direct printing protocol using deep UVs.
Azioune, A., Carpi, N., Quingzong, T., Théry, M., Piel, M.
Methods Cell Biology. 2010;97;133-146.

Patch-based nonlocal functional for denoising fluorescence microscopy image sequences.
Boulanger, J., Kervrann, C., Bouthemy, P., Elbau, P., Sibarita, JB., Salamero, J.
IEEE Trans Med Imaging. 2010;29;442-454.

Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier.
Brachet, A., Leterrier, C., Irondelle, M., Fache, MP., Racine, V., Sibarita, JB., Choquet, D., Dargent, B.
J Cell Biol. 2010;191;383-395.

Inaugural Article: Fast live simultaneous multiwavelength four-dimensional optical microscopy.
Carlton, PM., Boulanger, J., Kervrann, C., Sibarita, JB., Salamero, J., Gordon-Messer, S., Bressan, D., Haber, JE., Haase, S., Shao, L., Winoto, L., Matsuda, A., Kner, P., Uzawa, S., Gustafsson, M., Kam, Z., Agard, DA., Sedat, JW.
Proc Natl Acad Sci USA..

Dynamic Superresolution Imaging of Endogenous Proteins on Living Cells at Ultra-High Density.
Giannone, G., Hosy, E., Levet, F., Constals, A., Schulze, K., Sobolevsky, AI., Rosconi, MP., Gouaux, E., Tampé, R., Choquet, D., Cognet, L.
Biophysical Journal. 2011;99(4);1303-1310.

Managing micrometric sources of solvated electrons: application to the local functionnalization of fluorinated self assembled monolayers.
Ktari, N., Nunige, S., Azioune, A., Piel, M., Connan, C., Kanoufi, F., Combellas C.
Chemistry of Materials. 2010;22;5725-5731.


Enhanced hot-electron localization and heating in high-contrast ultraintense laser irradiation of microcone targets.
Rassuchine, J., d’Humieres, E., Baton, SD., Guillou, P., Koenig, M., Chahid, M., Perez, F., Fuchs J., Audebert, P., Kodama, R., Nakatsutsumi, M., Ozaki, N., Batani, D., Morace, A,. Redaelli, R., Gremillet, L., Rousseaux, C., Dorchies, F., Fourment, C., Santos, JJ., Adams, J., Korgan, G., Malekos, S., Hansen, SB., Shepherd, R., Flippo, K., Gaillard, S., Sentoku, Y., Cowan TE.
Physical review E., 2009;Statistical, nonlinear, and soft matter physics;79;036408.

Simple and rapid process for single cell micro-patterning.
Azioune, A., Storch, M., Bornens, M., Théry, M., Piel, M.
Lab Chip. 2009;9;1640-1642.

Activity-dependent tuning of inhibitory neurotransmission based on GABAAR diffusion dynamics.
Bannai, H., Levi, S., Schweizer, C., Inoue, T., Launey, T., Racine, V., Sibarita, JB., Mikoshiba, K., Triller, A.
Neuron. 2009;62;670-682.

AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis.
Delevoye, C., Hurbain, I., Tenza, D., Sibarita, JB., Uzan-Gafsou, S., Ohno, H., Geerts, WJ., Verkleij, AJ., Salamero, J., Marks, MS., Raposo G.
J Cell Biol. 2009;187;247-264.

The gene responsible for Dyggve-Melchior-Clausen syndrome encodes a novel peripheral membrane protein dynamically associated with the Golgi apparatus.
Dimitrov, A., Paupe, V., Gueudry, C., Sibarita, JB., Raposo, G., Vielemeyer, O., Gilbert, T., Csaba, Z., Attie-Bitach, T., Cormier-Daire, V., Gressens, P., Rustin, P., Perez, F., El Ghouzzi, V.
Hum Mol Genet. 2009;18;440-453.

Classical cadherins control nucleus and centrosome position and cell polarity.
Dupin, I., Camand, E., Etienne-Manneville, S.
J Cell Biol. 2009;185;779-86.

ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis.
Montagnac, G., Sibarita, JB., Loubery, S., Daviet, L., Romao, M., Rapsoso, G., Chavrier, P.
Curr Biol. 2009;19;184-195.

Microfluidic stickers for cell- and tissue-based assays in microchannels.
Morel, M., Bartolo, D., Galas, JC., Dahan, M., Studer, V.
Lab on a Chip. 2009;9;1011-1013.

Active connectors for microfluidic drops on demand.
Galas, JC., Bartolo, D., Studer V.
New Journal of Physics. 11.