Supervisory authorities


Presentation of the institute





Letellier M, Zsiber S, Chamma I, Saphy C, Papasideri I, Tessier B, Sainlos M, Czöndör K, Thoumine O.
A unique tyrosine in the intracellular domain of neuroligin-1 regulates AMPA receptor recruitment during excitatory synapse differentiation and potentiation.
Nat Commun 9:3979.

Haas KT, Compans B, Letellier M, Bartol TM, Grillo-Bosch D, Sejnowski TJ, Sainlos M, Choquet D, Thoumine O, Hosy E.
Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency.
Elife Jul 25;7. pii: e31755.

Chamma I, Thoumine O. Dynamics.
Nanoscale organization, and function of synaptic adhesion molecules.
Mol Cell Neurosci. Sep;91:95-107.


Thoumine O, Marchot P.
A triad of crystals shed new light on MDGA interference with neuroligation. Invited preview.
Neuron 95, 729-732.

Chamma I, Rossier O., Giannone G, Thoumine O*, Sainlos M*. (*Co-last authors). Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin.
Nature Protocols, Apr;12(4):748-763.

Czöndör K, Thoumine O.
Synaptogenic Assays Using Neurons Cultured on Micropatterned Substrates.
Methods Mol Biol. 1538:29-44.

Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Geyser A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M.
Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Nat Commun. Apr 7;8:14907.


Chamma I, Letellier M, Butler, Tessier B, Lim KH, Gauthereau I, Choquet D, Sibarita JB, Park S, Sainlos M*, Thoumine O* (*Co-last authors).
Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin.
Nat Commun, 7:10773 . Highlight in Nature Methods 13, 290 Improved protein labeling for super-resolution microscopy.

Chamma I, Levet F, Sibarita JB, Sainlos M, Thoumine O.
Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy.
Neurophotonics Oct;3(4):041810.

Fièvre S, Carta M, Chamma I, Labrousse V, Thoumine O, Mulle C.
Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells.
Nat Commun. Sep 27;7:12738.


Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O’Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J.
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.
Neuron. Aug 19;87(4):764-80.

Garcia, M, Leduc C, Lagardère M, Argento A, Sibarita JB, Thoumine O.
Two-tiered coupling between flowing actin and immobilized N-cadherin/catenin complexes in growth cones.
PNAS 112(22):6997-7002.

Chazeau A, Garcia M, Czöndör K, Perrais P, Tessier B, Giannone G, Thoumine O.
A mechanical coupling between N-cadherin adhesions and the F-actin flow stabilizes dendritic spines.
Mol Biol Cell, Mar 1;26(5):859-73.


Letellier M, Elramah S, Mondin M, Penn A, Choquet D, Landry M, Thoumine O*, Favereaux A* (*equal contributors)
miR-92a regulates translation and synaptic incorporation of GluA1 containing AMPA receptors during homeostatic scaling.
Nat Neurosci. 17(8):1040-2.

Chazeau A, Mehidi A, Nair D, Gautier JJ, Leduc C, Chamma I, Kage F, Kechkar A, Thoumine O, Rottner K, Sibarita JB, Giannone G.
Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.
EMBO J. 33, 2745–2764.


Mondin M, Tessier B, Thoumine O.
Assembly of synapses: biomimetic assays to control neurexin/neuroligin interactions at the neuronal surface.
Curr Protoc Neurosci. Jul 2013;Chapter 2:Unit2.19.

Czöndör K, Garcia M, Argento A, Constals A, Breillat C, Tessier B, Thoumine O.
Micropatterned substrates coated with neuronal adhesion proteins for high-content study of synapse formation.
Nat Commun. Aug 12;4:2252

Giannone G*, Mondin M*, Grillo-Bosch D, Tessier B, Saint-Michel E, Czöndör K, Sainlos M, Choquet D($), Thoumine O($).
Neurexin-1β binding to neuroligin-1 triggers the preferential recruitment of PSD-95 versus gephyrin through tyrosine phosphorylation of neuroligin-1.
Cell Reports, 27;3(6):1996-2007. (*) co-first authors; ($) co-last authors.

Czöndör K, Thoumine O.
Biophysical mechanisms regulating AMPA receptor accumulation at synapses.
Brain Res Bull. 93:57-68.


Czöndör K, Mondin M, Garcia M, Heine M, Frischknecht R, Choquet D, Sibarita JB, Thoumine O.
A unified quantitative model of AMPA receptor trafficking at synapses.
Proc Natl Acad Sci USA. 109(9):3522-7.

Czöndör K, Garcia M. THOUMINE O. PATENT n° PCT/FR2012/051688 July 2012, Micropatterned substrates for neuronal cell cultures and applications.


Mondin M, Labrousse V, Hosy E, Heine M, Tessier B, Levet F, Poujol C, Blanchet C, Choquet D, Thoumine O.
Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds.
J Neurosci 31:13500-15.

Favereaux A, Thoumine O, Bouali-Benazzouz R, Roques V, Papon MA, Salam SA, Drutel G, Léger C, Calas A, Nagy F, Landry M.
Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain.
EMBO J. 30:3830-41.


Giannone G, Mège RM, Thoumine O.
Multi-level molecular clutches in motile cell processes.
Trends Cell Biol 19, 475-786.

Saint-Michel E, Giannone G, Choquet D, Thoumine O.
Neurexin/neuroligin interaction kinetics characterized by counting single cell-surface attached quantum dots.
Biophys J 97:480-489.


Heine* M, Thoumine O*, Mondin M, Tessier B, Giannone G, Choquet D.
Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts.
PNAS 105:20947-20952 (* equal contributors).

Thoumine O, Ewers H, Heine M, Groc L, Frischknecht R, Giannone G, Poujol C, Legros P, Lounis B, Cognet L, Choquet D.
Probing the dynamics of protein-protein interactions at neuronal contacts by optical imaging.
Chem Rev 108:1565-1587.

Bard L, Boscher C, Lambert M, Mège RM, Choquet D, Thoumine O.
A molecular clutch between the actin flow and N-cadherin adhesions drives growth cone migration.
J Neurosci 28:5879-5890.


Breillat C, Thoumine O, Choquet D.
Characterization of SynCAM surface trafficking using a SynCAM derived ligand with high homophilic binding affinity.
Biochem Biophys Res Commun 359, 655-659.

Dequidt C, Danglot L, Alberts P, Galli T, Choquet D, Thoumine O.
Fast turnover of L1 adhesions in neuronal growth cones involving both surface diffusion and exo/endocytosis of L1 molecules.
Mol Biol Cell 18:3131-3143.

Saglietti L, Dequidt C, Kamieniarz K, Rousset MC, Valnegri P, Thoumine O, Beretta F, Fagni L, Choquet D, Sala C, Sheng M, Passafaro M.
Extracellular interactions between GluR2 and N-cadherin in spine regulation.
Neuron 54:461-77.


Thoumine O, Lambert M, Mège RM, Choquet D.
Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling.
Mol Biol Cell 17, 862-875.


Thoumine O, Saint-Michel E, Dequidt C, Falk J. Rudge R, Galli T, Faivre Sarrailh C, Choquet D.
Weak Effect of Membrane Diffusion on the Rate of Receptor Accumulation at Adhesive Contacts.
Biophys J 89, L40-42.


Falk J, Thoumine O, Dequidt C, Choquet D, Faivre-Sarrailh C.
NrCAM coupling to the cytoskeleton depends on multiple protein domains and partitioning into lipid rafts.
Mol Biol Cell 15, 4695-4709. F1000 Recommended Factor 3.0.