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Presentation of the institute



Synapse in Cognition

Team Leader: Yann Humeau

Yann Humeau is a tenured CNRS Investigator since 2008. After achieving his graduate studies (University of Rennes), he moved to the University of Strasbourg where he received a PhD in Neuroscience in 2002 under the supervision of Bernard Poulain. He then joined the lab of Pr Andreas Luthi (Friedrich Miescher Institute, Basel, Switzerland) as a post-doctoral fellow (2002-2004). In 2004, he joined the CNRS as a junior investigator in Strasbourg (UPR 2356), and started the "SynIQ" project dedicated to the study of the synaptic deficits associated with cognitive disorders.

Since 2011 he is leading the ATIP+ team "Synapse in Cognition" at IINS in Bordeaux.

Yann Humeau was awarded by the Pfizer price for scientific research (2006) and the bronze medal of the CNRS (2008).

Contact: Yann-Humeau, tel. +33 (0) 5 33 51 47 03

Project Summary

"Synapses are plastic. They change their efficacy depending on various parameters, including the respective activities of pre- and post-synaptic neurons. Numerous in vitro studies explored the plasticity repertoire of numerous synaptic populations in the mouse brain, but rarely according to endogenous inducers. It is no doubt that synaptic plasticity is associated and mediates learning and memory, thus our goal is to identify the neuronal activities that are associated with the learning and execution of cognitive abilities, and to understand how, when and where synaptic plasticity is generated.

We are developing cooperative in vivo and in vitro strategies to study the link between synapse and cognition. These include behavioral tests, in vivo pharmacology and optogenetic, and in vitro electrophysiological recording in various brain regions of identified synaptic populations.

Future main projects will focus on various phases of spatial learning, and will require our transition towards in vivo electrophysiological recordings in behaving mice."

Team expertise