Supervisory authorities


Presentation of the institute




"If I have seen further it is by standing on the shoulders of giants"
Isaac Newton, 1676

Key Publications

1. Zhang C.L., Aime M., Laheranne E., Houbaert X., El Oussini H., Martin C., Lepleux M., Normand E., Chelly J., Herzog E., Billuart P. and Humeau Y. (2017).
Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency. J Neurosci. 37(46): 11114-11126.

2. Penn A.C*, Zhang C.L.*, Georges F., Royer L., Breillat C., Hosy E, Petersen J.D., Humeau Y#. and Choquet D#. (2017).
Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature. 549(7672): 384-388. (co-first authors; # co-last authors).

3. Houbaert, X., Zhang, CL., Gambino, F., Lepleux, M., Deshors, M., Normand, E., Levet, F., Ramos, M., Billuart, P., Chelly, J., Herzog, E., Humeau, Y. (2013).
Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder. J. Neurosci. 33, 13805–13819.

4. Humeau Y., Herry C., Kemp N., Shaban H., Fourcaudot E., Bissière S., Lüthi A. (2005).
Dendritic spine heterogeneity determines afferent-specific Hebbian plasticity in the amygdala. Neuron 45, 119-31.

5. Humeau Y., Shaban H., Bissiere S., Lüthi A. (2003).
Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain. Nature 426, 841-845.

All Publications


Zhang H.Y., Zhang C.L., Vincent J., Zala D., Benstaali C., Sainlos M., Grillo-Bosch D., Daburon S., Coussen F., Cho Y., David D.J., Saudou F., Humeau Y., & Choquet D.
Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models. Nature communications, in press. doi: 10.1038/s41467-018-06675-3.


Dubos A., Meziane H., Iacono G., Curie A., Riet F., Martin., Loaëc N., Birling M.C., Selloum M., Normand E., Pavlovic G., Sorg T., Stunnenberg H. G., Chelly J., Humeau Y., Friocourt G., and Hérault al
A new mouse model of ARX dup24 recapitulates the patients’ behavioural and fine motor alterations. Human molecular genetics, 27(12):2138–2153. doi: 10.1093/hmg/ddy122.


Zhang C.L., Aime M., Laheranne E., Houbaert X., El Oussini H., Martin C., Lepleux M., Normand E., Chelly J., Herzog E., Billuart P. and Humeau Y.
Protein Kinase A deregulation in the medial prefrontal cortex impairs working memory in murine Oligophrenin1 deficiency. J. Neurosci.


Aincy M, Meziane H, Herault Y, Humeau Y.
Synaptic dysfunction in amygdala in intellectual disorder models. Prog Neuropsychopharmacol Biol Psychiatry 2017, 10.1016/j.pnpbp.2017.07.028.


Penn, A C, Zhang, C L, Georges, F, Royer, L, Breillat, C, Hosy, E, Petersen, J D, Humeau, Y and Choquet, D (2017) Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature 2017, 10.1038/nature23658.


Arbogast T, Iacono G, Chevalier C, Afinowi N, Houbaert X, van Eede M, Laliberté C, Birling MC, Selloum M, Linda K, Meziane H, Sorg T, Nadif Kasri N, Koolen D, Stunnenberg H, Henkelman M, Kopanitsa M, Humeau Y, de Vries B, Herault Y (2017). Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition, synaptic transmission and neurogenesis. PLoS Genetics 2017, 10.1371/journal.pgen.1006886


Meziane H, Khelfaoui M, Morello N, Hiba B, Calcagno E, Reibel-Foisset S, Selloum M, Chelly J, Humeau Y, Riet F, Zanni G, Herault Y, Bienvenu T, Giustetto M, Billuart P.
Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.
Hum Mol Genet 2016 Jun 1;25(11):2314-2323.


Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y.
Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.
Hum Mol Genet 2015 Dec 1;24(23):6736-55. doi: 10.1093/hmg/ddv380.


Ramos-Brossier M, Montani C, Lebrun N, Gritti L, Martin C, Seminatore-Nole C, Toussaint A, Moreno S, Poirier K, Dorseuil O, Chelly J, Hackett A, Gecz J, Bieth E, Faudet A, Heron D, Frank Kooy R, Loeys B, Humeau Y, Sala C, Billuart P.
Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis.
Hum Mol Genet 2015 Feb 15;24(4):1106-18. doi: 10.1093/hmg/ddu523.


Zhang, C.L.#, Houbaert X.#, Lepleux M., Deshors M., Normand E., Gambino F., Herzog E., and Humeau Y.
The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability.
Brain Structure and Function, 2014, doi: 10.1007/s00429-014-0882-x, (# equal contributors)

Heck N., Dos Santos M., Amairi B., Salery M., Besnard A., Herzog E., Boudier T., Vanhoutte P., Caboche J.
A new automated 3D detection of synaptic contacts reveals the formation of cortico-striatal synapses upon cocaine treatment in vivo.
Brain Structure and Function, 2014, BSAF-D-14-00199R2, in press


Jayachandran, R., Liu, X., BoseDasgupta, S., Mueller, P., Zhang, C.L., Moshous, D., Studer, V., Schneider, J., Genoud, C., Fossoud, C., Gambino, F., Khelfaoui, M., Müller, C., Bartholdi, C., Rossez, H., Stiess, M., Houbaert, X., Jaussi, R., Frey, D., Kammerer, R.A., Deupi, X., de Villartay, J.P., Lüthi, A., Humeau, Y.*, and Pieters, J*.
Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein kinase A Signaling.
PLoS Biology, 12, e1001820. (*co-corresponding authors)

Biesemann, C., Grønborg, M., Luquet, E., Wichert, S.P., Bernard, V., Bungers, S.R., Cooper, B., Varoqueaux, F., Li, L., Byrne, .A., Urlaub, H., Jahn, O., Brose, N., Herzog, E.
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
The EMBO journal, 33: 157-170


Ammar, M.R., Humeau, Y., Hanauer, A., Nieswandt, B., Bader, M.F., Vitale, N.
The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid.
J Neurosci, 33:19470-19479


Khelfaoui M., Gambino F., Houbaert X., Ragazzon B., Müller C., Carta M., Lanore F., Srikumar B.N., Gastrein P., Lepleux M., Zhang C.L., Kneib M., Poulain B., Reibel-Foisset S., Vitale N., Chelly J., Billuart P., Lüthi A. and Humeau Y.
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signaling pathway.
Philosophical Transactions B, 369, 20130160


Houbaert X.#, Zhang C.L.#, Gambino F., Lepleux M., Deshors M., Normand E., Levet F., Ramos M., Billuart P., Chelly J., Herzog E. and Humeau Y.
Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder.
J Neurosci. 33:13805-13819. #equal contribution

Siksou L., Silm K., Biesemann C., Nehring R.B., Wojcik S.M., Triller A., El Mestikawy, S., Marty S., Herzog E.
A role for vesicular glutamate transporter 1 in synaptic vesicle clustering and mobility.
Eur J Neurosci. 37:1631-1642


Li D., Hérault K., Silm K., Evrard A., Wojcik S., Oheim M., Herzog E., Ropert N.
Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes.
J Neurosci. 33:4434-4455


Blaise S., Kneib M., Rousseau A., Gambino F., Chenard M.P., Muckenstrum M., Alpy F., Tomasetto C., Humeau Y., Rio M.C.
In vivo evidence that TRAF4 is required for CNS myelin homeostasis and inhibits MAG-/Nogo-A-induced NgR/p75NTR/RhoA signaling pathway.
Plos One e30917


Bianchi V.#, Gambino F.#, Muzio L., Toniolo D., Humeau Y. and D’Adamo P.
Forebrain deletion of αGDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections.
Plos One e29763. #equal contribution


Humeau Y, Candiani S, Ghirardi M, Poulain B, Montarolo P.
Functional roles of synapsin: Lessons from invertebrates.
Seminars in Cell and Developmental Biology, 22: 425-433


Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, Kirchhoff F, Brose N.
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice.
J Neurosci. 31:15544-15559


Doussau F, Humeau Y, Benfenati F, Poulain B.
A novel form of presynaptic plasticity based on the fast reactivation of release sites switched off during low frequency depression.
J Neurosci. 49:16679-16691


Gambino F, Khelfaoui M, Poulain B, Bienvenu T, Chelly J, Humeau Y.
Synaptic maturation at cortical projections to the lateral amygdala in a mouse model of Rett syndrome.
PLoS One, 5:e11399


Pavlowsky A, Gianfelice A, Pallotto M, Zanchi A, Vara H, Khelfaoui M, Valnegri P, Rezai X, Bassani S, Brambilla D, Kumpost J, Blahos J, Roux MJ, Humeau Y, Chelly J, Passafaro M, Giustetto M, Billuart P, Sala C.
A postsynaptic Signaling Pathway that may Account for the cognitive Defect Due to IL1RAPL1 Mutation.
Current Biology, 20:103-115